Department of Epidemiology Hubert Department of Global Health, Rollins School of Public Health, Emory University.
Department of Epidemiology Hubert Department of Global Health, Rollins School of Public Health, Emory University Department of Medicine, Division of Infectious Diseases Influenza Pathogenesis and Immunology Research Center.
Clin Infect Dis. 2015 Mar 1;60(5):e11-9. doi: 10.1093/cid/ciu915. Epub 2014 Nov 18.
Despite strong evidence that maternal influenza vaccination during pregnancy is safe, uptake of influenza vaccination during pregnancy remains low. We identified studies that assessed outcomes of stillbirth or spontaneous abortion after administration of influenza vaccine during pregnancy. We conducted a literature search in November 2013 that yielded 447 total citations. After removal of duplicates and studies deemed not relevant based on the title and abstract, 36 records underwent a full text review and 7 studies were included in the final review. Where possible, adjusted results were included in the meta-analysis. Women in the influenza vaccine group had a lower likelihood of stillbirth (relative risk [RR], 0.73; 95% confidence interval [CI], .55-.96); this association was similar when restricted to the H1N1pdm09 vaccine (RR, 0.69; 95% CI, .53-.90). The pooled estimate for spontaneous abortion was not significant (RR, 0.91; 95% CI, .68-1.22). These analyses add to the evidence base for the safety of influenza vaccination in pregnancy.
尽管有强有力的证据表明孕妇接种流感疫苗是安全的，但孕妇对流感疫苗的接种率仍然很低。我们确定了评估孕妇接种流感疫苗后死产或自然流产结局的研究。我们于 2013 年 11 月进行了文献检索，共得到 447 条参考文献。剔除重复项和根据标题及摘要认为不相关的研究后，有 36 篇文献进行了全文审查，最终有 7 篇文献纳入了最终审查。只要有可能，就将调整后的结果纳入荟萃分析。流感疫苗组的女性发生死产的可能性较低（相对风险 [RR]，0.73；95%置信区间 [CI]，0.55-0.96）；当仅限于 H1N1pdm09 疫苗时，这种关联也相似（RR，0.69；95% CI，0.53-0.90）。自然流产的汇总估计值不显著（RR，0.91；95% CI，0.68-1.22）。这些分析增加了流感疫苗在孕期使用安全性的证据基础。
