Huang Fang, Zhu Jingjing, Qiu Jing, Li Juan, Liao Yuting, Li Zhi, Huang Zhuoying, Guo Xiang, Sun Xiaodong
Institute of Immunization, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hum Vaccin Immunother. 2025 Dec;21(1):2523091. doi: 10.1080/21645515.2025.2523091. Epub 2025 Aug 12.
Pregnant women are at elevated risk of severe influenza-related complications and maternal influenza vaccination protects mothers and infants. Nevertheless, the global maternal influenza vaccination rates remain critically low. This cross-sectional survey, conducted in Shanghai during 2023-2024, applied the Health Belief Model (HBM) to evaluate the attitudes and determinants of seasonal influenza vaccination among 3219 pregnant women. Only 10.9% (351/3219) accepted the vaccination, while 89.1% (1851/3219) declined, including 35.4% (1017/3219) who expressed uncertainty. Key facilitators of acceptance included higher education (graduate degree and above: adjusted odds ratio (aOR) = 2.49) and a greater total influenza knowledge score (aOR = 1.07). Strong HBM constructs, including perceived susceptibility (aOR = 1.53), perceived severity (aOR = 1.66), and belief in vaccine benefit (aOR = 2.55) significantly predicted vaccine uptake. The most influential factor was cues to action (aOR = 8.55). Conversely, safety concerns for maternal and fetal health dominated hesitancy, overshadowing other barriers. As the first HBM-based study to assess the attitude to influenza vaccination among pregnant women in China, these findings revealed low baseline awareness and confidence among Shanghai's population of pregnant women. This study highlighted an urgent need to strengthen provider-patient communication to amplify "cues to action," and integrated vaccination advocacy into routine prenatal care. Addressing these barriers could align vaccination rates with global maternal health priorities, leveraging dual protection for mothers and infants.
孕妇患严重流感相关并发症的风险较高,而孕产妇接种流感疫苗可保护母亲和婴儿。然而,全球孕产妇流感疫苗接种率仍然极低。这项横断面调查于2023年至2024年在上海进行,应用健康信念模型(HBM)评估了3219名孕妇对季节性流感疫苗接种的态度和决定因素。只有10.9%(351/3219)的孕妇接受了疫苗接种,而89.1%(1851/3219)的孕妇拒绝接种,其中35.4%(1017/3219)表示不确定。接受接种的关键促进因素包括高等教育(研究生及以上学历:调整优势比(aOR)=2.49)和更高的流感知识总分(aOR=1.07)。强大的健康信念模型结构,包括感知易感性(aOR=1.53)、感知严重性(aOR=1.66)和对疫苗益处的信念(aOR=2.55)显著预测了疫苗接种情况。最具影响力的因素是行动线索(aOR=8.55)。相反,对母婴健康的安全担忧主导了犹豫态度,超过了其他障碍。作为中国第一项基于健康信念模型评估孕妇对流感疫苗接种态度的研究,这些发现揭示了上海孕妇群体的基线认知和信心较低。这项研究强调迫切需要加强医患沟通以放大“行动线索”,并将疫苗接种宣传纳入常规产前护理。克服这些障碍可以使疫苗接种率与全球孕产妇健康优先事项保持一致,实现对母亲和婴儿的双重保护。