内源性大麻素对神经细胞的编程作用：从生理规则到新兴疗法。
Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies.
机构信息
1] School of Medicine and Center of Integrated Research, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, I-00128 Rome, Italy. [2] European Center for Brain Research/Santa Lucia Foundation, Via del Fosso di Fiorano 65, I-00143 Rome, Italy.
Department of Biochemistry and Molecular Biology I and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Complutense University, E-28040 Madrid, Spain.
出版信息
Nat Rev Neurosci. 2014 Dec;15(12):786-801. doi: 10.1038/nrn3846.
Abstract
Among the many signalling lipids, endocannabinoids are increasingly recognized for their important roles in neuronal and glial development. Recent experimental evidence suggests that, during neuronal differentiation, endocannabinoid signalling undergoes a fundamental switch from the prenatal determination of cell fate to the homeostatic regulation of synaptic neurotransmission and bioenergetics in the mature nervous system. These studies also offer novel insights into neuropsychiatric disease mechanisms and contribute to the public debate about the benefits and the risks of cannabis use during pregnancy and in adolescence.
摘要
在众多信号脂质中，内源性大麻素因其在神经元和神经胶质发育中的重要作用而日益受到关注。最近的实验证据表明，在内生性大麻素信号传导过程中，在神经元分化过程中，信号传导经历了从产前细胞命运决定到成熟神经系统中突触神经传递和生物能量的稳态调节的基本转变。这些研究还为神经精神疾病机制提供了新的见解，并为关于妊娠和青春期使用大麻的益处和风险的公众辩论做出了贡献。
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