Tan Yaqian, Xia Hui, Song Qi
Department of Pharmacy, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China.
Front Pharmacol. 2025 Apr 2;16:1540619. doi: 10.3389/fphar.2025.1540619. eCollection 2025.
The cannabinoids and endocannabinoid system are thought to play critical roles in multiple signaling pathways in organisms, and extensive evidence from preclinical studies indicated that cannabinoids and endocannabinoids displayed anticancer potential. This study aimed to summarize the research of cannabinoids and endocannabinoid system in cancer through bibliometric analysis.
Relevant literature in the field of cannabinoids and endocannabinoid system in cancer published during 1995-2024 were collected from the Web of Science Core Collection database. VOSviewer and SCImago Graphica were applied to perform bibliometric analysis of countries, institutions, authors, journals, documents, and keywords.
A total of 3,052 publications were identified, and the global output exhibited a generally upward trend over the past 3 decades. The USA had the greatest number of publications and citations in this research field. Italian National Research Council led in terms of publication, while Complutense University of Madrid had the highest total citations. Vincenzo Di Marzo was the leading author in this field with the greatest number of publications and citations. The co-occurrence of keywords revealed that the research frontiers mainly included "cannabinoids", "endocannabinoid system", "cancer", "anandamide", "cannabidiol", "cannabinoid receptor", "apoptosis", and "proliferation".
Our results revealed that the research of cannabinoids and endocannabinoid system in cancer would receive continuous attention. The USA and Italy have made remarkable contributions to this field, supported by their influential institutions and prolific scholars. The research emphasis has evolved from basic functional characterization to mechanistic exploration of disease pathways and translational applications within multidisciplinary framework.
大麻素和内源性大麻素系统被认为在生物体的多种信号通路中发挥关键作用，临床前研究的大量证据表明大麻素和内源性大麻素具有抗癌潜力。本研究旨在通过文献计量分析总结大麻素和内源性大麻素系统在癌症方面的研究。
从科学引文索引核心合集数据库收集1995 - 2024年期间发表的关于大麻素和内源性大麻素系统在癌症领域的相关文献。应用VOSviewer和SCImago Graphica对国家、机构、作者、期刊、文献和关键词进行文献计量分析。
共确定了3052篇出版物，在过去三十年中全球产出总体呈上升趋势。美国在该研究领域的出版物数量和被引次数最多。意大利国家研究委员会在出版物数量方面领先，而马德里康普顿斯大学的总被引次数最高。Vincenzo Di Marzo是该领域发表论文和被引次数最多的主要作者。关键词共现显示，研究前沿主要包括“大麻素”、“内源性大麻素系统”、“癌症”、“花生四烯乙醇胺”、“大麻二酚”、“大麻素受体”、“细胞凋亡”和“增殖”。
我们的结果表明，大麻素和内源性大麻素系统在癌症方面的研究将持续受到关注。美国和意大利在其有影响力的机构和多产学者的支持下，对该领域做出了显著贡献。研究重点已从基本功能表征演变为在多学科框架内对疾病途径的机制探索和转化应用。
