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[双侧睾丸肿瘤:原位癌诊断在早期检测中的作用]

[Bilateral tumors of the testis: the role of the diagnosis of carcinoma in situ in early detection].

作者信息

Houlgatte A, Houdelette P, Berlizot P, Fournier R, Bernard O, Schill H

机构信息

Clinique d'Urologie, Hôpital d'Instruction des Armées du Val de Grâce, Paris.

出版信息

Prog Urol. 1995 Sep;5(4):540-3.

PMID:7581504
Abstract

In a series of 540 patients with testicular germ cell tumors, the diagnosis of bilateral tumor was observed nine times. Two patients presented a simultaneous bilateral tumor and for seven others a second tumor occurred after an interval varying from 1 to 16 years. The often late discovery of the contralateral cancer sometimes requires a prolonged follow up for patients with unilateral testicular malignancy. Incidence, risk factors and therapy are discussed, in particular the anomalies in testicular migration, hypofertility, testicular atrophy and carcinoma in situ. Prevention of bilateral consecutive tumors depends on the research of carcinoma in situ thanks to testicular biopsy. A slight radiotherapy allows eradication of this tumor, whose evolution towards invading cancer is particularly high. A rigorous watch of these patients can be considered. With the absence of early detection, the treatment of the simultaneous tumor needs taking into consideration the treatment of the initial tumor. In case of a diagnosis at stage 1, observation after orchidectomy is possible without further treatment.

摘要

在一组540例睾丸生殖细胞肿瘤患者中,观察到9例双侧肿瘤的诊断情况。2例患者同时出现双侧肿瘤,另外7例患者在1至16年不等的间隔期后出现了第二个肿瘤。对侧癌症往往发现较晚,这有时需要对单侧睾丸恶性肿瘤患者进行长期随访。本文讨论了发病率、危险因素和治疗方法,特别是睾丸迁移异常、生育力低下、睾丸萎缩和原位癌。通过睾丸活检研究原位癌有助于预防双侧连续性肿瘤。轻微的放射治疗可根除这种肿瘤,其向浸润性癌发展的可能性特别高。可以考虑对这些患者进行严格监测。由于缺乏早期检测,同时性肿瘤的治疗需要考虑初始肿瘤的治疗。如果在1期诊断,睾丸切除术后观察即可,无需进一步治疗。

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