Reinhold H S, van den Berg-Blok A E
Radiobiological Institute TNO, Rijswijk and Erasmus University, Rotterdam, The Netherlands.
Eur J Cancer Clin Oncol. 1989 Apr;25(4):611-8. doi: 10.1016/0277-5379(89)90194-6.
The response of the microcirculation in five different tumours, growing in 'sandwich' observation chambers in the back of the rat, to hyperthermia was investigated. The tumours investigated encompassed three human xenografted tumours, of which two were carcinomata of the colon and one of the lung, and two isologous rat tumours, the Rhabdomyosarcoma BA1112 and a rat mammary carcinoma. It was concluded (1) that the various tumours required significantly different exposure times for inducing 50% stoppage of the tumour microcirculation (ST50). This seems to indicate that differences in the characteristics of the tumour cells are more important for causing microcirculatory stoppage than is the sensitivity of the cells of the blood vessels. (2) An increase in surface (i.e. volume) was observed in all four tumours examined for this phenomenon. The rate of increase (usually 1-2% per hour at 42.5 degrees C) was, however, significantly different between the various tumours. This rate was higher exposure temperatures (43 and 43.5 degrees C), but this was only investigated for the Rhabdomyosarcoma BA1112. Extensive statistical analysis of this phenomenon of volume increase could not demonstrate a correlation with any of the circulation parameters. (3) The relative velocity of the erythrocytes in selected capillaries in the tumours decreases as a result of the hyperthermic treatment, and is probably related to the tumour-specific ST50. (4) A human colon carcinoma xenograft, one of the tumours investigated, showed strong fluctuations in the parameter 'erythrocyte velocity'. The appearance of such fluctuations did not seem to influence the heat-induced stoppage of the circulation. Probably the phenomenon of fluctuations in the velocities of the erythrocytes in the tumour capillaries is a tumour-specific phenomenon.
研究了生长在大鼠背部“三明治”观察室中的五种不同肿瘤的微循环对热疗的反应。所研究的肿瘤包括三种人异种移植肿瘤，其中两种是结肠癌，一种是肺癌，以及两种同种大鼠肿瘤，即横纹肌肉瘤BA1112和大鼠乳腺癌。得出的结论如下：（1）各种肿瘤诱导肿瘤微循环50%停滞（ST50）所需的暴露时间有显著差异。这似乎表明，肿瘤细胞特征的差异对导致微循环停滞比血管细胞的敏感性更为重要。（2）在所检查的所有四种肿瘤中均观察到表面积（即体积）增加。然而，各种肿瘤之间的增加速率（在42.5摄氏度时通常为每小时1-2%）有显著差异。在较高暴露温度（43和43.5摄氏度）下该速率更高，但仅对横纹肌肉瘤BA1112进行了此项研究。对这种体积增加现象的广泛统计分析未能证明与任何循环参数存在相关性。（3）热疗导致肿瘤中选定毛细血管内红细胞的相对速度降低，这可能与肿瘤特异性ST50有关。（4）所研究的肿瘤之一人结肠癌异种移植瘤在“红细胞速度”参数上表现出强烈波动。这种波动的出现似乎并不影响热诱导的循环停滞。肿瘤毛细血管中红细胞速度波动的现象可能是一种肿瘤特异性现象。
