中脑导水管周围灰质中γ-氨基丁酸A受体的阻断消除了伤害性脊髓背角神经元的活动。
Blockade of GABAA receptors in the midbrain periaqueductal gray abolishes nociceptive spinal dorsal horn neuronal activity.
作者信息
Sandkühler J, Willmann E, Fu Q G
机构信息
Universität Heidelberg II, Physiologisches Institut, F.R.G.
出版信息
Eur J Pharmacol. 1989 Jan 24;160(1):163-6. doi: 10.1016/0014-2999(89)90667-5.
Single spinal dorsal horn neuronal responses to noxious skin heating or innocuous skin brushing were recorded in pentobarbital anesthetized rats. The heat-evoked activity was selectively abolished by blockade of GABAA receptors in the midbrain periaqueductal grey (PAG) by microinjections of 40 or 400 pmol bicuculline. It is concluded that antinociceptive output neurons in the PAG that trigger descending inhibition are maximally active when released from tonic GABAergic inhibition.
在戊巴比妥麻醉的大鼠中记录了单个脊髓背角神经元对有害皮肤加热或无害皮肤轻刷的反应。通过微量注射40或400 pmol荷包牡丹碱阻断中脑导水管周围灰质（PAG）中的GABAA受体，选择性地消除了热诱发的活动。得出的结论是，当从紧张性GABA能抑制中释放出来时，触发下行抑制的PAG中的抗伤害感受输出神经元具有最大活性。
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