Özcan Sedat, Odabasi Dolunay, Kurt Tolga, Gür Ali Kemal, Kunt Aysegul, Balaharoglu Yavuz, Kunt Alper Sami
Department of Cardiovascular Surgery, Faculty Of Medicine, 18 Mart University, Canakkale, Turkey.
Department of Cardiovascular Surgery, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
Wien Klin Wochenschr. 2015 Oct;127(19-20):764-9. doi: 10.1007/s00508-014-0652-z. Epub 2014 Nov 20.
Although some studies indicate an association between increased levels of estradiol and varicose veins in women, the role of sex hormones on varicose veins have a question mark in men.
We investigated estradiol-2/free testosterone (E2/fT) ratio relationship on varicosity in 100 male patients dividing them into two groups. Group A (n = 46) had varicose veins with endocrinological problems, especially infertility, whereas group B (n = 54) also had varicose veins but no endocrinological problems. Venous blood samples were drawn from both groups in the morning to detect the levels of serum estradiol (E2), androstenedione, dehydroepiandrostenedione sulphate and free testosterone (fT). Patient history, physical examination, colour duplex ultrasound of both limbs and classification of CEAP were performed in both groups. Serum E2/fT ratio was calculated in correspondence with CEAP classification. CEAP classification is the varicosity classification, and it is concerned about the clinical class (C), etiology (E), anatomical distribution (A) and underlying pathophysiology (P).
E2/fT ratio was significantly higher in group A (4.18 ± 0.54) compared with group B (2.98 ± 0.36). Moreover, there is a high correlation between serum E2/fT ratio and CEAP clinical classification in group A (4) compared with group B (2).
Serum E2/fT ratio is associated with varicose veins in male patients.
尽管一些研究表明女性体内雌二醇水平升高与静脉曲张之间存在关联，但性激素在男性静脉曲张中的作用仍存在疑问。
我们将100名男性患者分为两组，研究雌二醇-2/游离睾酮（E2/fT）比值与静脉曲张的关系。A组（n = 46）患有静脉曲张并伴有内分泌问题，尤其是不育症；而B组（n = 54）也有静脉曲张，但没有内分泌问题。两组均于早晨采集静脉血样，检测血清雌二醇（E2）、雄烯二酮、硫酸脱氢表雄酮和游离睾酮（fT）水平。两组均进行了病史采集、体格检查、双下肢彩色超声检查以及CEAP分类。根据CEAP分类计算血清E2/fT比值。CEAP分类是静脉曲张分类，它涉及临床分级（C）、病因（E）、解剖分布（A）和潜在病理生理学（P）。
A组的E2/fT比值（4.18±0.54）显著高于B组（2.98±0.36）。此外，与B组（2）相比，A组（4）血清E2/fT比值与CEAP临床分级之间存在高度相关性。
血清E2/fT比值与男性患者的静脉曲张有关。
