van den Beld A W, Bots M L, Janssen J A M L L, Pols H A P, Lamberts S W J, Grobbee D E
Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Am J Epidemiol. 2003 Jan 1;157(1):25-31. doi: 10.1093/aje/kwf160.
The aging process is characterized by a number of gradual changes in circulating hormone concentrations as well as a gradual increase in the degree of atherosclerosis. The authors studied whether serum hormone levels are related to atherosclerosis of the carotid artery in independently living, elderly men. In 1996, 403 men (aged 73-94 years) were randomly selected from the general population of Zoetermeer, the Netherlands. Carotid artery intima-media thickness was determined. Serum concentrations of testosterone; estrone; estradiol; dehydroepiandrosterone and dehydroepiandrosterone sulfate; insulin-like growth factor I (IGF-I) (total and free) and its binding proteins IGFBP-1, IGFBP-2, and IGFBP-3; and leptin were measured. After the authors adjusted for age, serum testosterone, estrone, and free IGF-I were inversely related to intima-media thickness. The strength of these relations was as powerful in subjects with as in those without prevalent cardiovascular disease. Serum estradiol; dehydroepiandrosterone sulfate; total IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3; and leptin showed no association. These findings suggest that endogenous testosterone, estrone, and free IGF-I levels may play a protective role in the development of atherosclerosis in aging men.
衰老过程的特征是循环激素浓度出现一些逐渐变化，以及动脉粥样硬化程度逐渐增加。作者研究了血清激素水平是否与独立生活的老年男性的颈动脉粥样硬化有关。1996年，从荷兰祖特梅尔的普通人群中随机选取了403名男性（年龄在73 - 94岁之间）。测定了颈动脉内膜中层厚度。测量了血清睾酮、雌酮、雌二醇、脱氢表雄酮和硫酸脱氢表雄酮、胰岛素样生长因子I（IGF - I）（总浓度和游离浓度）及其结合蛋白IGFBP - 1、IGFBP - 2和IGFBP - 3，以及瘦素的浓度。在作者对年龄进行校正后，血清睾酮、雌酮和游离IGF - I与内膜中层厚度呈负相关。在患有和未患有心血管疾病的受试者中，这些关系的强度相同。血清雌二醇、硫酸脱氢表雄酮、总IGF - I、IGFBP - 1、IGFBP - 2和IGFBP - 3以及瘦素未显示出相关性。这些发现表明，内源性睾酮、雌酮和游离IGF - I水平可能在老年男性动脉粥样硬化的发展中起保护作用。
