双相情感障碍患者终身自杀未遂、血清脂质水平与代谢综合征之间的关系。
The relationship between lifetime suicide attempts, serum lipid levels, and metabolic syndrome in patients with bipolar disorders.
作者信息
Shakeri Jalal, Farnia Vahid, Valinia Katayoun, Hashemian Amir Hossein, Bajoghli Hafez, Holsboer-Trachsler Edith, Brand Serge
机构信息
Department of Psychiatry, Behavioral Sciences Research Center, Kermanshah University of Medical Sciences , Kermanshah , Iran.
出版信息
Int J Psychiatry Clin Pract. 2015 Jun;19(2):124-31. doi: 10.3109/13651501.2014.988271. Epub 2014 Dec 16.
OBJECTIVES
To assess the relationship between lifetime suicide attempts (SAs), serum lipid values, and metabolic syndrome (MetS) in patients with bipolar disorders (BPD).
METHODS
Eighty patients with BPD took part in the study (M = 40.60 years). After psychiatric diagnosis, demographic data, SAs, and serum lipids were measured and MetS was calculated.
RESULTS
70% reported at least one suicide attempt. 52.5% suffered from MetS. Suicide attempters had higher cholesterol values. SAs were associated with a family history of suicide, current mood state, and lower educational level. SAs were unrelated to MetS.
CONCLUSIONS
In patients with BPD, against expectations, the occurrence of SAs was associated with higher cholesterol values. Serum lipid values are not suitable as a biological trait marker to predict SAs.
目的
评估双相情感障碍（BPD）患者终生自杀未遂（SA）、血清脂质值与代谢综合征（MetS）之间的关系。
方法
80例BPD患者参与了该研究（平均年龄40.60岁）。经过精神科诊断后，测量了人口统计学数据、SA及血清脂质，并计算了MetS。
结果
70%的患者报告至少有一次自杀未遂。52.5%的患者患有MetS。自杀未遂者的胆固醇值较高。SA与自杀家族史、当前情绪状态及较低教育水平相关。SA与MetS无关。
结论
在BPD患者中，出乎意料的是，SA的发生与较高的胆固醇值相关。血清脂质值不适宜作为预测SA的生物学特征标志物。
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