Quagliato Lucas Barasnevicius, Domingues Carolina, Quagliato Elizabeth Maria Aparecida Barasnevicius, Abreu Elvira Barbosa de, Kara-Junior Newton
Departament of Ophthalmology, Universidade Estadual de Campinas, SP, Brazil.
Departament of Neurology, Universidade Estadual de Campinas, SP, Brazil.
Arq Bras Oftalmol. 2014 Aug;77(4):238-42. doi: 10.5935/0004-2749.20140061.
The goal of this cross-sectional observational study was to quantify the pattern-shift visual evoked potentials (VEP) and the thickness as well as the volume of retinal layers using optical coherence tomography (OCT) across a cohort of Parkinson's disease (PD) patients and age-matched controls.
Forty-three PD patients and 38 controls were enrolled. All participants underwent a detailed neurological and ophthalmologic evaluation. Idiopathic PD cases were included. Cases with glaucoma or increased intra-ocular pressure were excluded. Patients were assessed by VEP and high-resolution Fourier-domain OCT, which quantified the inner and outer thicknesses of the retinal layers. VEP latencies and the thicknesses of the retinal layers were the main outcome measures.
The mean age, with standard deviation (SD), of the PD patients and controls were 63.1 (7.5) and 62.4 (7.2) years, respectively. The patients were predominantly in the initial Hoehn-Yahr (HY) disease stages (34.8% in stage 1 or 1.5, and 55.8 % in stage 2). The VEP latencies and the thicknesses as well as the volumes of the retinal inner and outer layers of the groups were similar. A negative correlation between the retinal thickness and the age was noted in both groups. The thickness of the retinal nerve fibre layer (RNFL) was 102.7 μm in PD patients vs. 104.2 μm in controls.
The thicknesses of retinal layers, VEP, and RNFL of PD patients were similar to those of the controls. Despite the use of a representative cohort of PD patients and high-resolution OCT in this study, further studies are required to establish the validity of using OCT and VEP measurements as the anatomic and functional biomarkers for the evaluation of retinal and visual pathways in PD patients.
这项横断面观察性研究的目的是，通过光学相干断层扫描（OCT）对一组帕金森病（PD）患者和年龄匹配的对照者进行视网膜层厚度、体积以及图形翻转视觉诱发电位（VEP）的量化分析。
招募了43例PD患者和38名对照者。所有参与者均接受了详细的神经学和眼科评估。纳入特发性PD病例。排除青光眼或眼压升高的病例。通过VEP和高分辨率傅里叶域OCT对患者进行评估，后者可量化视网膜层的内层和外层厚度。VEP潜伏期和视网膜层厚度是主要观察指标。
PD患者和对照者的平均年龄（标准差）分别为63.1（7.5）岁和62.4（7.2）岁。患者主要处于早期Hoehn-Yahr（HY）疾病阶段（1期或1.5期占34.8%，2期占55.8%）。两组的VEP潜伏期、视网膜内层和外层的厚度及体积相似。两组均发现视网膜厚度与年龄呈负相关。PD患者的视网膜神经纤维层（RNFL）厚度为102.7μm，对照者为104.2μm。
PD患者的视网膜层厚度、VEP和RNFL与对照者相似。尽管本研究使用了具有代表性的PD患者队列和高分辨率OCT，但仍需要进一步研究以确定将OCT和VEP测量作为评估PD患者视网膜和视觉通路的解剖学和功能生物标志物的有效性。
