Svetel Marko, Marić Gorica, Božić Marija, Lazić Una, Milovanović Andona, Jakšić Jana, Petrović Igor, Dimitrijević Ana, Knežević Milica, Pekmezović Tatjana
Clinic for Eye Disease, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Institute of Epidemiology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Biomedicines. 2025 May 19;13(5):1227. doi: 10.3390/biomedicines13051227.
: Certain aspects of retinal thickness assessed by optical coherence tomography (OCT) in patients with Parkinson's disease (PD) require additional clarification. It is supposed that attributing reduced retinal thickness in PD to dopaminergic loss may not be acceptable as it also happens in diseases where dopaminergic loss does not occur. The objective of our study is to compare the ganglion cell/inner plexiform layer (GCIPL), peripapillary retinal nerve fiber layer (pRNFL), and macular thickness of PD and dopa responsive dystonia (DRD) patients with healthy controls (HC), to investigate whether DRD patients, as a distinctive model of genetically induced dopamine deficiency, have reduced retinal thickness in comparison with PD, and to analyze correlation between retinal thickness and various PD clinical parameters. : We analyzed 86 patients with PD, 10 patients with DRD, and 96 age- and sex-matched HC. : GCIPL, pRNFL, and central macula thickness (CMT) are statistically significantly thinner in PD patients compared to HC ( < 0.001, all). GCIPL and CMT are also statistically significantly thinner in DRD patients compared to HC ( = 0.012, = 0.001, respectively). GCIPL thickness correlates positively with the daily dose of levodopa (r = 0.244, < 0.01). The thickness of GCIPL and pRNFL correlate negatively with current age (r = -0.219; < 0.01 and r = -0.358; < 0.05, respectively). All retinal parameters are statistically significantly thinner in females than in males ( < 0.05). : Patients with PD and DRD did not differ in GCIPL and pRNFL thickness when compared to one another. These results, supported by positive correlation of levodopa dose and GCIPL thickness in PD patients, emphasize the importance of dopamine in maintaining retinal thickness.
帕金森病（PD）患者通过光学相干断层扫描（OCT）评估的视网膜厚度的某些方面需要进一步阐明。认为将PD患者视网膜厚度降低归因于多巴胺能缺失可能并不合理，因为在未发生多巴胺能缺失的疾病中也会出现这种情况。我们研究的目的是比较PD和多巴反应性肌张力障碍（DRD）患者与健康对照（HC）的神经节细胞/内丛状层（GCIPL）、视乳头周围视网膜神经纤维层（pRNFL）和黄斑厚度，调查作为基因诱导多巴胺缺乏独特模型的DRD患者与PD相比视网膜厚度是否降低，并分析视网膜厚度与各种PD临床参数之间的相关性。
我们分析了86例PD患者、10例DRD患者以及96例年龄和性别匹配的HC。
与HC相比，PD患者的GCIPL、pRNFL和中心黄斑厚度（CMT）在统计学上显著更薄（均P<0.001）。与HC相比，DRD患者的GCIPL和CMT在统计学上也显著更薄（分别为P = 0.012，P = 0.001）。GCIPL厚度与左旋多巴日剂量呈正相关（r = 0.244，P<0.01）。GCIPL和pRNFL厚度与当前年龄呈负相关（分别为r = -0.219，P<0.01和r = -0.358，P<\u003c0.05）。所有视网膜参数在女性中均比男性在统计学上显著更薄（P<0.05）。
PD和DRD患者相互比较时，GCIPL和pRNFL厚度没有差异。PD患者中左旋多巴剂量与GCIPL厚度的正相关支持了这些结果，强调了多巴胺在维持视网膜厚度中的重要性。
