Stemplewitz Birthe, Keserü Matthias, Bittersohl Diana, Buhmann Carsten, Skevas Christos, Richard Gisbert, Hassenstein Andrea
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Acta Ophthalmol. 2015 Dec;93(8):e672-7. doi: 10.1111/aos.12764. Epub 2015 Jun 10.
Whether retinal degeneration is part of the degenerative processes in patients with Parkinson's disease (PD) is still unclear. This cross-sectional study was undertaken to compare the retinal morphology of patients with PD and healthy controls using spectral domain optical coherence tomography (SD-OCT) and scanning laser polarimetry (SLP).
Both eyes of patients with PD (n = 108) and healthy controls (n = 165) were examined using SD-OCT and SLP on the same day. Data on the thickness of the retinal nerve fibre layer (RNFL) of all quadrants and the macular area were acquired by OCT (Cirrus, Zeiss). The SLP device (Glaucoma diagnostics (GDx), Zeiss) measured the RNFL and calculated the nerve fibre index (NFI). All patients and probands were checked for concomitant ocular disorders by an ophthalmologist. Visual acuity, intraocular pressure (IOP), objective refraction and the anterior and posterior segment were assessed.
Patients with PD showed a reduced macular volume and a reduced central subfield thickness in OCT examinations. The RNFL in the different quadrants did not differ significantly from that of controls. SLP data showed a reduced average RNFL thickness, a decreased thickness of the inferior quadrant and an increase of the NFI in patients with PD.
PD may be associated with reduced thickness and volume of the macula and a reduced thickness of the RNFL in the inferior quadrant of the retina. Investigations using SD-OCT and SLP revealed distinct but significant differences between patients with PD and healthy controls.
视网膜变性是否为帕金森病（PD）患者退行性病变过程的一部分仍不明确。本横断面研究旨在使用频域光学相干断层扫描（SD - OCT）和扫描激光偏振仪（SLP）比较PD患者与健康对照者的视网膜形态。
在同一天使用SD - OCT和SLP对PD患者（n = 108）和健康对照者（n = 165）的双眼进行检查。通过OCT（蔡司Cirrus）获取所有象限及黄斑区视网膜神经纤维层（RNFL）厚度的数据。SLP设备（蔡司青光眼诊断仪（GDx））测量RNFL并计算神经纤维指数（NFI）。所有患者和受试者均由眼科医生检查是否伴有眼部疾病。评估视力、眼压（IOP）、客观验光以及眼前节和眼后节情况。
在OCT检查中，PD患者显示黄斑体积减小和中心子区域厚度降低。不同象限的RNFL与对照组相比无显著差异。SLP数据显示，PD患者平均RNFL厚度降低，下象限厚度减小，NFI增加。
PD可能与黄斑厚度和体积减小以及视网膜下象限RNFL厚度降低有关。使用SD - OCT和SLP进行的研究揭示了PD患者与健康对照者之间存在明显但显著的差异。
