猫的体型与代谢指标及左心室肥厚的关系
Relationship of body size to metabolic markers and left ventricular hypertrophy in cats.
作者信息
Freeman L M, Rush J E, Feugier A, van Hoek I
机构信息
Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA.
出版信息
J Vet Intern Med. 2015 Jan;29(1):150-6. doi: 10.1111/jvim.12503. Epub 2014 Nov 20.
BACKGROUND
Cats with hypertrophic cardiomyopathy (HCM) are larger and have higher insulin-like growth factor-1 (IGF-1) concentrations than cats without HCM.
HYPOTHESIS/OBJECTIVES: The aim of this study was to assess echocardiographic findings in a colony of adult cats to determine the relationship between early growth and left ventricular hypertrophy (LVH).
ANIMALS
Twenty-eight neutered adult cats (20 males, 8 females) from a colony ≥ 3 years of age for which growth curves were available.
METHODS
Case-control study. Physical examination and echocardiography were performed, and body weight, body condition score (BCS), and head length and width were measured. Circulating glucose, insulin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and IGF-1 concentrations were measured and growth data were collected. Stepwise multivariate analyses were performed.
RESULTS
Mean age was 5.2 ± 1.1 years. Current BCSs ranged from 4 to 9 (median, 6) and mean body weight was 4.88 ± 1.29 kg. Variation in body weight was apparent by 6 (mean = 3.26 ± 0.80 kg) and 12 months of age (mean = 4.02 ± 1.02 kg). Cardiac abnormalities included a cardiac murmur (n = 7; 24%), gallop (n = 3; 10%), and arrhythmia (n = 1; 4%). Fourteen of 28 cats (50%) had echocardiographic evidence of LVH. Head width (P = .017), body weight (P < .001), NT-proBNP (P = .023), and IGF-1 (P = .013-.022) were significantly associated with selected measures of LVH.
CONCLUSIONS AND CLINICAL IMPORTANCE
Potential associations between body size, IGF-1, LVH, and HCM warrant future prospective studies.
背景
与未患肥厚型心肌病（HCM）的猫相比，患HCM的猫体型更大，胰岛素样生长因子-1（IGF-1）浓度更高。
假设/目的：本研究的目的是评估一群成年猫的超声心动图检查结果，以确定早期生长与左心室肥厚（LVH）之间的关系。
动物
来自一个群体的28只绝育成年猫（20只雄性，8只雌性），年龄≥3岁，有生长曲线数据。
方法
病例对照研究。进行体格检查和超声心动图检查，测量体重、身体状况评分（BCS）以及头的长度和宽度。测量循环葡萄糖、胰岛素、N末端B型脑钠肽前体（NT-proBNP）和IGF-1浓度，并收集生长数据。进行逐步多变量分析。
结果
平均年龄为5.2±1.1岁。当前BCS范围为4至9（中位数为6），平均体重为4.88±1.29千克。6个月（平均=3.26±0.80千克）和12个月龄（平均=4.02±1.02千克）时体重变化明显。心脏异常包括心杂音（n = 7；24%）、奔马律（n = 3；10%）和心律失常（n = 1；4%）。28只猫中有14只（50%）有LVH的超声心动图证据。头宽（P = 0.017）、体重（P < 0.001）、NT-proBNP（P = 0.023）和IGF-1（P = 0.013 - 0.022）与LVH的选定测量指标显著相关。
结论及临床意义
体型、IGF-1、LVH和HCM之间的潜在关联值得未来进行前瞻性研究。
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