Wu Tzu-Yu, Rouse Andrew R, Chambers Setsuko K, Hatch Kenneth D, Gmitro Arthur F
University of Arizona, College of Optical Sciences, 1630 East University Boulevard, Tucson, Arizona 85721, United StatesbUniversity of Arizona, Department of Medical Imaging, PO Box 245067, Tucson, Arizona 85724, United States.
University of Arizona, College of Optical Sciences, 1630 East University Boulevard, Tucson, Arizona 85721, United StatesbUniversity of Arizona, Department of Medical Imaging, PO Box 245067, Tucson, Arizona 85724, United StatescUniversity of Arizona Cancer.
J Biomed Opt. 2014 Nov;19(11):116010. doi: 10.1117/1.JBO.19.11.116010.
Recent evidence suggests that ovarian cancer can originate in the fallopian tube. Unlike many other cancers, poor access to the ovary and fallopian tubes has limited the ability to study the progression of this deadly disease and to diagnosis it during the early stage when it is most amenable to therapy. A rigid confocal microlaparoscope system designed to image the epithelial surface of the ovary in vivo was previously reported. A new confocal microlaparoscope with an articulating distal tip has been developed to enable in vivo access to human fallopian tubes. The new microlaparoscope is compatible with 5-mm trocars and includes a 2.2-mm-diameter articulating distal tip consisting of a bare fiber bundle and an automated dye delivery system for fluorescence confocal imaging. This small articulating device should enable the confocal microlaparoscope to image early stage ovarian cancer arising inside the fallopian tube. Ex vivo images of animal tissue and human fallopian tube using the new articulating device are presented along with in vivo imaging results using the rigid confocal microlaparoscope system.
近期证据表明，卵巢癌可能起源于输卵管。与许多其他癌症不同，难以触及卵巢和输卵管限制了对这种致命疾病进展的研究能力，以及在最适合治疗的早期阶段对其进行诊断的能力。此前曾报道过一种用于在体内对卵巢上皮表面进行成像的刚性共聚焦微型腹腔镜系统。现已开发出一种具有可弯曲远端尖端的新型共聚焦微型腹腔镜，以实现对人体输卵管的体内观察。这种新型微型腹腔镜与5毫米套管针兼容，包括一个直径为2.2毫米的可弯曲远端尖端，由一束裸光纤和一个用于荧光共聚焦成像的自动染料输送系统组成。这种小型可弯曲装置应能使共聚焦微型腹腔镜对输卵管内早期卵巢癌进行成像。本文展示了使用这种新型可弯曲装置对动物组织和人体输卵管进行的体外图像，以及使用刚性共聚焦微型腹腔镜系统进行的体内成像结果。
