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通过大环 Gd(III) 配合物的自组装来优化高场弛豫率。

Optimizing the high-field relaxivity by self-assembling of macrocyclic Gd(III) complexes.

机构信息

Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza, 52, 10126, Torino, Italy.

出版信息

Dalton Trans. 2015 Mar 21;44(11):4910-7. doi: 10.1039/c4dt02971b.

DOI:10.1039/c4dt02971b
PMID:25411928
Abstract

Using recognition moieties that bind to the inner co-ordination sphere of a monomeric DO3A-type di-aqua complex, dimeric poly(aminocarboxylate) gadolinium(III) compounds can be formed with greatly enhanced relaxivities, arising from optimized contributions of inner- and second spheres of hydration.

摘要

利用与单核 DO3A 型二水合配合物的内配位球结合的识别部分,可以形成具有大大增强的弛豫率的二聚多(氨基羧酸)钆(III)化合物,这是由于内和第二水合层的优化贡献所致。

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