Ordooei Mahtab, Shojaoddiny-Ardekani Ahmad, Hoseinipoor Seyed H, Miroliai Mehrdad, Zare-Zardini Hadi
Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Minerva Pediatr. 2017 Oct;69(5):391-395. doi: 10.23736/S0026-4946.16.04145-1. Epub 2014 Nov 20.
Studies show the relationship between vitamin D deficiency and glucose metabolism disorders. The aim of this study was the evaluation of the effect of vitamin D administration in management of diabetes mellitus type 1 (T1D).
We evaluated the effect of supplementation with vitamin D on HbA1c levels of children and adolescents with T1D. In this before-after study, 70 subjects with T1D were enrolled. Fasting serum 25-hydroxyvitamin D, calcium, phosphate, alkaline phosphatase, glucose and HbA1c were measured at the initiation and after the administration of 50,000 IU of vitamin D3 biweekly for 3 months. The results were then compared using paired t-test. Between 70 patients, five patients were excluded from the study because they did not completed the study and finally 65 subjects finished the study.
Sixty-five patients including 35 children and 30 adolescents were recruited. Forty-three (66.1%) subjects had vitamin D deficiency (<30 ng/mL). Vitamin D administration leads to decrease of fast blood sugar and HbA1c levels significantly in treated group without effect on calcium and alkaline phosphatase levels. So, no significant alterations occurred in calcium and alkaline phosphatase levels after supplementation with vitamin D.
This study showed that HbA1c may be reduced by administration of vitamin D to children and adolescents with T1D without changing the dose of insulin.
研究表明维生素D缺乏与糖代谢紊乱之间存在关联。本研究的目的是评估补充维生素D对1型糖尿病（T1D）治疗的影响。
我们评估了补充维生素D对T1D儿童和青少年糖化血红蛋白（HbA1c）水平的影响。在这项前后对照研究中，纳入了70例T1D患者。在开始时以及每两周给予50,000 IU维生素D3共3个月后，测量空腹血清25-羟维生素D、钙、磷、碱性磷酸酶、血糖和HbA1c。然后使用配对t检验比较结果。70例患者中，有5例因未完成研究而被排除，最终65例受试者完成了研究。
招募了65例患者，包括35名儿童和30名青少年。43例（66.1%）受试者存在维生素D缺乏（<30 ng/mL）。补充维生素D后，治疗组的空腹血糖和HbA1c水平显著降低，而对钙和碱性磷酸酶水平无影响。因此，补充维生素D后钙和碱性磷酸酶水平无显著变化。
本研究表明，在不改变胰岛素剂量的情况下，给予T1D儿童和青少年维生素D可降低HbA1c水平。
