Hafez Mona, Hassan Mona, Musa Noha, Abdel Atty Sahar, Azim Sally Abdel
Diabetes, Endocrine and Metabolism Pediatric Unit, Cairo University, Cairo.
Lecturer of Pediatrics, Diabetes, Endocrine and Metabolism Pediatric Unit, Pediatric Department, Cairo University, Cairo.
J Pediatr Endocrinol Metab. 2017 Apr 1;30(4):389-394. doi: 10.1515/jpem-2016-0292.
The association of low serum 25 hydroxy cholecalciferol (25OHD) levels with high glucose level and diminished insulin sensitivity suggests that vitamin D (VD) may modulate insulin metabolism. The aim of the study was to screen for vitamin D deficiency (VDD) in pediatric patients with type 1 diabetes (T1D) and study the effect of VD supplementation on their glycemic control and insulin requirements.
A prospective cohort study including 50 patients with T1D. VD level was assessed initially and after 3 months of VD supplementation (in those with VDD). HbA1c and insulin requirements were studied at 0, 3 and 6 months of supplementation.
Fifty patients with T1D were included with mean diabetes duration of 4.11±2.34 years. VD level ranged from 0.2 to 33 ng/mL. VD status correlated significantly with daily insulin dose (p=0.030, r=0.306) and HbA1c (p<0.001, r=0.243). Thirty-five patients (70%) had VDD and were allocated for VD supplementation for 3 months. The mean HbA1c improved significantly after supplementation (p=0.003), followed by a significant deterioration at 6 months with no change in their insulin requirements at 3 or 6 months.
VD was highly prevalent in Egyptian T1D patients. VD supplementation improved glycemic control at 3 months after therapy with no reduction in insulin requirements.
低血清25羟胆钙化醇（25OHD）水平与高血糖水平及胰岛素敏感性降低相关，提示维生素D（VD）可能调节胰岛素代谢。本研究旨在筛查1型糖尿病（T1D）患儿中的维生素D缺乏（VDD）情况，并研究补充VD对其血糖控制和胰岛素需求量的影响。
一项前瞻性队列研究，纳入50例T1D患者。最初评估VD水平，并在补充VD 3个月后（针对VDD患者）再次评估。在补充VD的0、3和6个月时研究糖化血红蛋白（HbA1c）和胰岛素需求量。
纳入50例T1D患者，糖尿病平均病程为4.11±2.34年。VD水平范围为0.2至33 ng/mL。VD状态与每日胰岛素剂量显著相关（p = 0.030，r = 0.306），与HbA1c也显著相关（p < 0.001，r = 0.243）。35例患者（70%）存在VDD，并被分配接受3个月的VD补充治疗。补充后平均HbA1c显著改善（p = 0.003），随后在6个月时显著恶化，3个月或6个月时胰岛素需求量无变化。
VD在埃及T1D患者中高度流行。补充VD在治疗3个月后改善了血糖控制，且胰岛素需求量未降低。
