IRCCS-Mario Negri Institute for Pharmacological Research, Milan, Italy.
Neuroepidemiology. 2014;43(3-4):228-32. doi: 10.1159/000368801. Epub 2014 Nov 20.
To estimate the prevalence and incidence of epilepsy in Italy using a national database of general practitioners (GPs).
The Health Search CSD Longitudinal Patient Database (HSD) has been established in 1998 by the Italian College of GPs. Participants were 700 GPs, representing a population of 912,458. For each patient, information on age and sex, EEG, CT scan, and MRI was included. Prevalent cases with a diagnosis of 'epilepsy' (ICD9CM: 345*) were selected in the 2011 population. Incident cases of epilepsy were identified in 2011 by excluding patients diagnosed for epilepsy and convulsions and those with EEG, CT scan, MRI prescribed for epilepsy and/or convulsions in the previous years. Crude and standardized (Italian population) prevalence and incidence were calculated.
Crude prevalence of epilepsy was 7.9 per 1,000 (men 8.1; women 7.7). The highest prevalence was in patients <25 years and ≥75 years. The incidence of epilepsy was 33.5 per 100,000 (women 35.3; men 31.5). The highest incidence was in women <25 years and in men 75 years or older.
Prevalence and incidence of epilepsy in this study were similar to those of other industrialized countries. HSD appears as a reliable data source for the surveillance of epilepsy in Italy.
利用意大利全科医生（GP）的国家数据库估计意大利的癫痫患病率和发病率。
健康搜索 CSD 纵向患者数据库（HSD）于 1998 年由意大利全科医生学院建立。参与者为 700 名全科医生，代表了 912,458 人的人口。为每位患者提供了年龄和性别、脑电图、计算机断层扫描和磁共振成像的信息。在 2011 年的人群中选择了诊断为“癫痫”（ICD9CM：345*）的现患病例。通过排除在以前的年份中诊断为癫痫和惊厥的患者以及脑电图、计算机断层扫描、磁共振成像因癫痫和/或惊厥而开具的患者，在 2011 年确定了癫痫的新发病例。计算了粗患病率和标准化（意大利人口）患病率和发病率。
癫痫的粗患病率为每 1000 人 7.9 例（男性 8.1；女性 7.7）。患病率最高的是<25 岁和≥75 岁的患者。癫痫的发病率为每 100,000 人 33.5 例（女性 35.3；男性 31.5）。发病率最高的是<25 岁的女性和≥75 岁的男性。
本研究中的癫痫患病率和发病率与其他工业化国家相似。HSD 似乎是意大利癫痫监测的可靠数据源。
