Walters Yasmin, Agius Mark
University of Cambridge, School of Clinical Medicine, St. Catharine's College, Cambridge, UK,
Psychiatr Danub. 2014 Nov;26 Suppl 1:285-8.
One of the major symptoms of schizophrenia is cognitive deficits. Despite this, these impairments still lack an effective treatment. It was hoped that atypical antipsychotics would treat these symptoms better than their first generation counterparts, but unfortunately the likes of quetiapine and clozapine did not do so. Asenapine and lurasidone, two newer atypicals, have shown promise, as have agents that interact with the glutamate system. Another approach has been to add agents such as modafinil. More research is needed to consolidate the findings of these studies.
精神分裂症的主要症状之一是认知缺陷。尽管如此，这些损伤仍缺乏有效的治疗方法。人们曾希望非典型抗精神病药物比第一代同类药物能更好地治疗这些症状，但不幸的是，喹硫平和氯氮平之类的药物并未达到预期效果。阿立哌唑和鲁拉西酮这两种较新的非典型药物已显示出前景，与谷氨酸系统相互作用的药物也是如此。另一种方法是添加如莫达非尼之类的药物。需要更多研究来巩固这些研究的结果。
