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一种专门的骨科并发症分级系统与关节置换术中早期不良结局之间的相关性。

Correlations between a dedicated orthopaedic complications grading system and early adverse outcomes in joint arthroplasty.

作者信息

Harris Dorothy Y, McAngus Jillian K, Kuo Yong-Fang, Lindsey Ronald W

机构信息

Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555-0165, USA,

出版信息

Clin Orthop Relat Res. 2015 Apr;473(4):1524-31. doi: 10.1007/s11999-014-4058-z. Epub 2014 Nov 21.

Abstract

BACKGROUND

Reliable classification of postoperative complications is important for quality improvement efforts. In 2014, The Knee Society proposed a grading system for complications after TKA, but to our knowledge, a relationship between complication grades and surgical outcomes has not yet been established.

QUESTIONS/PURPOSES: We attempted to determine (1) whether an association exists between complication grade and early adverse outcomes after TKA and THA, and (2) what proportion of the variability in complications could be associated with the classification grade (a metric of potential predictive value of the grading schema).

METHODS

A total of 210 primary THAs and TKAs in 201 patients performed at one center from January 1, 2011 to December 31, 2011 were reviewed; of those, 188 patients (94%; 197 procedures) had complete 90-day postoperative data and were evaluated retrospectively for postoperative complications. We defined and graded complications according to the classification system proposed by Iorio et al. and The Knee Society. Early adverse outcomes assessed included length of hospital stay and unplanned readmissions or reoperations. A total of 254 complications were documented in 135 patients (137 procedures); 53 patients (60 procedures) had no complications. Bivariate analyses were conducted to identify associations between complication grade and early adverse outcomes and patient variables; analyses considered patient variables including age, sex, status as a state prisoner (yes or no), American Society of Anesthesiologists score, BMI, and procedure (TKA or THA). Multiple regression and logistic regression analyses were conducted to determine the association between complication grade and early adverse outcomes (length of stay [LOS] and unplanned readmission or reoperations) adjusted for confounding patient variables. Alpha was set at 0.05 for two-sided tests.

RESULTS

Maximum complication grade (range, from 0-4) was associated with a longer LOS (for each point increase of maximum grade, LOS increased 0.105 ± 0.024 days, p < 0.001) and more readmissions or reoperations (odds ratio [OR], 3.79; 95% CI, 1.91-7.54; p < 0.001). Total grade (range, 0-22) also was associated with increased LOS (for each point increase of total grade, LOS increased 0.032 ± 0.006 days, p < 0.001) and increased readmissions or reoperations (OR, 1.34; 95% CI, 1.18-1.53; p < 0.001). Total grade could account for 38% of the variation in LOS and readmissions or reoperations (C-statistic = 0.94; 95% CI, 0.90-0.98); whereas maximum complication grade could account for 35% of the variation in LOS and readmissions or reoperations (C-statistic = 0.35; 95% CI, 0.88-0.96). Thus, we found total grade to be a slightly better predictor of LOS and readmissions or reoperations than maximum grade.

CONCLUSIONS

We found that the proposed grading system is applicable to TKA and THA in terms of documentation of complication severity and as an indicator of increased LOS and increased unplanned readmissions or reoperation rates. That total complication grade was a better predictor of LOS than maximum grade suggests that multiple complications of a lesser grade can be just as important as a single higher grade complication in terms of effect on outcomes.

摘要

背景

可靠的术后并发症分类对于质量改进工作很重要。2014年,膝关节协会提出了全膝关节置换术(TKA)后并发症的分级系统,但据我们所知,并发症分级与手术结果之间的关系尚未确立。

问题/目的:我们试图确定:(1)TKA和全髋关节置换术(THA)后并发症分级与早期不良结果之间是否存在关联;(2)并发症变异性的多大比例可能与分类分级相关(分级方案潜在预测价值的一个指标)。

方法

回顾了2011年1月1日至2011年12月31日在一个中心对201例患者进行的210例初次THA和TKA;其中,188例患者(94%;197例手术)有完整的术后90天数据,并对术后并发症进行回顾性评估。我们根据Iorio等人和膝关节协会提出的分类系统定义并分级并发症。评估的早期不良结果包括住院时间和非计划再入院或再次手术。共记录了135例患者(137例手术)的254例并发症;53例患者(60例手术)无并发症。进行双变量分析以确定并发症分级与早期不良结果及患者变量之间的关联;分析考虑了患者变量,包括年龄、性别、州立监狱囚犯身份(是或否)、美国麻醉医师协会评分、体重指数(BMI)和手术(TKA或THA)。进行多元回归和逻辑回归分析以确定在调整混杂患者变量后并发症分级与早期不良结果(住院时间[LOS]和非计划再入院或再次手术)之间的关联。双侧检验的α设定为0.05。

结果

最大并发症分级(范围为0 - 4)与更长的住院时间相关(最大分级每增加1分,住院时间增加0.105±0.024天,p<0.001)以及更多的再入院或再次手术(比值比[OR]为3.79;95%置信区间为1.91 - 7.54;p<0.001)。总分级(范围为0 - 22)也与住院时间增加相关(总分级每增加1分,住院时间增加0.032±0.006天,p<0.001)以及再入院或再次手术增加(OR为1.34;95%置信区间为1.18 - 1.53;p<0.001)。总分级可解释住院时间和再入院或再次手术变异性中的38%(C统计量 = 0.94;95%置信区间为0.90 - 0.98);而最大并发症分级可解释住院时间和再入院或再次手术变异性中的35%(C统计量 = 0.35;95%置信区间为0.88 - 0.96)。因此,我们发现总分级在预测住院时间和再入院或再次手术方面比最大分级稍好。

结论

我们发现,就并发症严重程度的记录以及作为住院时间增加和非计划再入院或再次手术率增加的指标而言,表示的分级系统适用于TKA和THA。总并发症分级比最大分级更能预测住院时间,这表明就对结果的影响而言,多个较低级别的并发症可能与单个较高级别的并发症同样重要。

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