基于结构的蛋白质：DNA特异性建模。
Structure-based modeling of protein: DNA specificity.
作者信息
Joyce Adam P, Zhang Chi, Bradley Philip, Havranek James J
出版信息
Brief Funct Genomics. 2015 Jan;14(1):39-49. doi: 10.1093/bfgp/elu044. Epub 2014 Nov 19.
Abstract
Protein:DNA interactions are essential to a range of processes that maintain and express the information encoded in the genome. Structural modeling is an approach that aims to understand these interactions at the physicochemical level. It has been proposed that structural modeling can lead to deeper understanding of the mechanisms of protein:DNA interactions, and that progress in this field can not only help to rationalize the observed specificities of DNA-binding proteins but also to allow researchers to engineer novel DNA site specificities. In this review we discuss recent developments in the structural description of protein:DNA interactions and specificity, as well as the challenges facing the field in the future.
摘要
蛋白质与DNA的相互作用对于一系列维持和表达基因组中编码信息的过程至关重要。结构建模是一种旨在从物理化学层面理解这些相互作用的方法。有人提出，结构建模能够加深对蛋白质与DNA相互作用机制的理解，并且该领域的进展不仅有助于阐明已观察到的DNA结合蛋白的特异性，还能使研究人员设计出新的DNA位点特异性。在本综述中，我们讨论了蛋白质与DNA相互作用及其特异性的结构描述方面的最新进展，以及该领域未来面临的挑战。
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