Institute of Health & Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow G12 8RZ, UK.
BMC Public Health. 2014 Nov 21;14:1197. doi: 10.1186/1471-2458-14-1197.
Health-related quality of life (HRQoL) is associated with adverse outcomes in disease-specific populations. This study examines whether it is also independent predictor of incident cancer, coronary heart disease (CHD) and mortality in the general population.
The records of adult participants in the Scottish Health Survey 2003 were linked with hospital admissions, cancer registrations and death certificates. Cox proportional hazard models were used to explore the associations between quintiles of physical and mental component summary score (PCS and MCS respectively) of the SF-12 and adverse outcomes. Higher quintiles of both PCS and MCS indicate better health status.
Among the 5,272 study participants, the mean PCS score was 49 (standard deviation (SD) 10.3). Participants were followed-up for a mean of 7.6 years. On survival analysis the lowest quintile of PCS was a strong predictor of all-cause death (hazard ratio (HR) 2.81, 95% CI 1.76, 4.49), incident cancer (HR 1.63, 95% CI 1.10, 2.42), and CHD events (HR 1.99, 95% CI 1.00, 3.96), compared to the highest quintile. This association was independent of adiposity and other confounders. The mean MCS score 52 (SD 8.8). MCS quintile was not associated with incident cancer and CHD, and the association between MCS and all-cause death (HR 1.33, 95% CI 1.01, 1.75) became non-significant after adjustment for adiposity.
Physical HRQoL is a significant predictor of a range of adverse outcomes, even after adjustment for adiposity and other confounders. This study highlights the importance of perceived health in the general population.
健康相关生活质量（HRQoL）与特定疾病人群的不良结局相关。本研究旨在探讨其是否也是一般人群中癌症、冠心病（CHD）和死亡的独立预测因素。
苏格兰健康调查 2003 年成年参与者的记录与住院记录、癌症登记和死亡证明相关联。使用 Cox 比例风险模型探讨 SF-12 量表身体成分和心理成分综合得分（PCS 和 MCS）五分位数与不良结局之间的关联。较高的 PCS 和 MCS 五分位数表明健康状况更好。
在 5272 名研究参与者中，平均 PCS 评分为 49（标准差 10.3）。参与者的平均随访时间为 7.6 年。生存分析显示，PCS 得分最低的五分位数是全因死亡（风险比 2.81，95%置信区间 1.76，4.49）、癌症发病（HR 1.63，95%置信区间 1.10，2.42）和 CHD 事件（HR 1.99，95%置信区间 1.00，3.96）的强预测因素，与最高分位数相比。这种关联独立于肥胖和其他混杂因素。平均 MCS 评分为 52（标准差 8.8）。MCS 五分位数与癌症和 CHD 无关，且 MCS 与全因死亡（HR 1.33，95%置信区间 1.01，1.75）之间的关联在调整肥胖后变得不显著。
身体 HRQoL 是一系列不良结局的重要预测因素，即使在调整肥胖和其他混杂因素后也是如此。本研究强调了一般人群中感知健康的重要性。
