利用主要剪接因子构建稳健的转录组。
Building robust transcriptomes with master splicing factors.
作者信息
Jangi Mohini, Sharp Phillip A
机构信息
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Cell. 2014 Oct 23;159(3):487-98. doi: 10.1016/j.cell.2014.09.054.
Abstract
Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or "master splicing factors," respond to environmental cues to establish and maintain tissue transcriptomes during development.
摘要
连贯的剪接网络源自许多协调调控的离散剪接决策。在此，我们研究稳健的、上下文特异性剪接网络的特性。我们提出，关键剪接调节因子的一个子集，即“主剪接因子”，在发育过程中响应环境线索以建立和维持组织转录组。
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