Vedernikova N N, Borisova I P, Orekhov S N
Biull Eksp Biol Med. 1989 Apr;107(4):456-8.
The male outbred rats, placed in common cages, demonstrated dose- and time-dependent increase of blood plasma ACTH level after handling and acute ethanol administration (1 and 4 g/kg). The pituitary response of isolated rats under condition of free choice between water and 15% ethanol solution was more pronounced after handling. Ethanol (4 g/kg) did not increase plasma blood level ACTH in isolated alcohol motivated rats. It also prevented blood plasma ACTH rise under condition of handling. The dual role of acute ethanol as a stressogenic and antistressogenic factor in naive and alcoholic rats is discussed.
将雄性远交系大鼠置于普通笼子中，在处理和急性给予乙醇（1克/千克和4克/千克）后，其血浆促肾上腺皮质激素（ACTH）水平呈剂量和时间依赖性增加。在处理后，在水和15%乙醇溶液之间可自由选择的条件下，分离出的大鼠的垂体反应更为明显。乙醇（4克/千克）并未使处于对酒精有动机的分离大鼠的血浆ACTH水平升高。它还在处理条件下阻止了血浆ACTH的升高。讨论了急性乙醇在未接触过乙醇的大鼠和酒精成瘾大鼠中作为应激源和抗应激源因子的双重作用。
