Obel J, Souares Y, Hoy D, Baravilala W, Garland S M, Kjaer S K, Roth A
Department of Obstetrics and Gynaecology, Hvidovre Hospital, Denmark E-mail :
Asian Pac J Cancer Prev. 2014;15(21):9433-7. doi: 10.7314/apjcp.2014.15.21.9433.
This study provides the first systematic literature review of cervical cancer incidence and mortality as well as human papillomavirus (HPV) genotype prevalence among women with cervical cancer in the Pacific Island countries and territories. The cervical cancer burden in the Pacific Region is substantial, with age standardized incidence rates ranging from 8.2 to 50.7 and age standardized mortality rate from 2.7 to 23.9 per 100,000 women per year. The HPV genotype distribution suggests that 70-80% of these cancers could be preventable by the currently available bi- or quadrivalent HPV vaccines. There are only few comprehensive studies examining the epidemiology of cervical cancer in this region and no published data have hitherto described the current cervical cancer prevention initiatives in this region.
本研究首次对太平洋岛国和领地宫颈癌的发病率、死亡率以及宫颈癌女性中人乳头瘤病毒（HPV）基因型流行情况进行了系统的文献综述。太平洋地区的宫颈癌负担沉重，年龄标准化发病率为每年每10万名女性8.2至50.7例，年龄标准化死亡率为每年每10万名女性2.7至23.9例。HPV基因型分布表明，目前可用的二价或四价HPV疫苗可预防70%-80%的此类癌症。该地区仅有少数全面研究宫颈癌流行病学的研究，迄今为止尚无已发表的数据描述该地区当前的宫颈癌预防举措。
