Porsolt R D, Deniel M, Jalfre M
Eur J Pharmacol. 1979 Aug 15;57(4):431-6. doi: 10.1016/0014-2999(79)90507-7.
Rats when forced to swim in a restricted space not only became immobile but showed marked hypothermia. The hypothermia was greater than that observed after reserpine or Ro 4-1284 and was not antagonized by imipramine at doses which significantly reduced immobility. Hypothermia induced by forced swimming can therefore be dissociated from the immobility occurring in these conditions and also from drug-induced hypothermia.
当被迫在有限空间游泳时，大鼠不仅变得不动，还出现明显的体温过低。这种体温过低比利血平或Ro 4-1284诱导的体温过低更严重，且在能显著减少不动时间的剂量下，丙咪嗪不能对抗这种体温过低。因此，强迫游泳诱导的体温过低可与这些条件下出现的不动状态以及药物诱导的体温过低区分开来。
