基于互补金属氧化物半导体（CMOS）图像传感器的可植入葡萄糖传感器，采用葡萄糖响应性荧光水凝胶。
CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel.
作者信息
Tokuda Takashi, Takahashi Masayuki, Uejima Kazuhiro, Masuda Keita, Kawamura Toshikazu, Ohta Yasumi, Motoyama Mayumi, Noda Toshihiko, Sasagawa Kiyotaka, Okitsu Teru, Takeuchi Shoji, Ohta Jun
机构信息
Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
TERUMO Co., R&D Headquarters, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan.
出版信息
Biomed Opt Express. 2014 Oct 10;5(11):3859-70. doi: 10.1364/BOE.5.003859. eCollection 2014 Nov 1.
Abstract
A CMOS image sensor-based implantable glucose sensor based on an optical-sensing scheme is proposed and experimentally verified. A glucose-responsive fluorescent hydrogel is used as the mediator in the measurement scheme. The wired implantable glucose sensor was realized by integrating a CMOS image sensor, hydrogel, UV light emitting diodes, and an optical filter on a flexible polyimide substrate. Feasibility of the glucose sensor was verified by both in vitro and in vivo experiments.
摘要
提出了一种基于光学传感方案的基于CMOS图像传感器的可植入葡萄糖传感器，并进行了实验验证。在测量方案中，使用葡萄糖响应荧光水凝胶作为介质。通过将CMOS图像传感器、水凝胶、紫外发光二极管和光学滤波器集成在柔性聚酰亚胺基板上，实现了有线可植入葡萄糖传感器。通过体外和体内实验验证了葡萄糖传感器的可行性。
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