IEEE Trans Biomed Circuits Syst. 2009 Jun;3(3):169-80. doi: 10.1109/TBCAS.2009.2016844.
A remotely powered implantable microsystem for continuous blood glucose monitoring is presented. The microsystem consists of a microfabricated glucose biosensor flip-chip bonded to a transponder chip. The transponder chip is inductively powered by an external reader with a 13.56-MHz carrier. It then measures the output signal of the glucose biosensor and transmits the measured data back to the external reader using load-shift keying (LSK). The microsystem has a volume of 32 mm(3). The procedures for the microfabrication of the glucose sensor and the assembly of the microsystem are described along with the description of the circuit blocks of the transponder chip. The transponder chip has been fabricated with the TSMC 0.18-mum CMOS process and has a total area of 1.3 x 1.3 mm(2). The chip can measure the sensor output current ranging from 1 nA to 1 muA with less than 0.3% nonlinearity error, provided that the amplitude of the received RF signal is higher than 2.6 V; the circuit consumes a total current of about 110 muA.
本文介绍了一种用于连续血糖监测的远程供电植入式微系统。该微系统由微加工葡萄糖生物传感器倒装芯片与转发器芯片键合而成。该转发器芯片通过外部阅读器以 13.56MHz 载波进行感应供电。然后，它测量葡萄糖生物传感器的输出信号，并使用负载移位键控（LSK）将测量数据传输回外部阅读器。该微系统的体积为 32mm3。本文描述了葡萄糖传感器的微加工过程和微系统的组装过程，以及转发器芯片的电路模块描述。该转发器芯片是采用 TSMC 0.18 微米 CMOS 工艺制造的，总面积为 1.3 x 1.3mm2。只要接收到的射频信号幅度高于 2.6V，该芯片就可以测量范围在 1nA 至 1uA 之间的传感器输出电流，且非线性误差小于 0.3%；该电路总共消耗约 110uA 的电流。
