非节段性泛发性白癜风患者血清中循环的白细胞介素-23水平升高。
Increased serum levels of interleukin-23 circulating in patients with non-segmental generalized vitiligo.
作者信息
Vaccaro Mario, Cannavò Serafinella P, Imbesi Selene, Cristani Mariateresa, Barbuzza Olga, Tigano Valeria, Gangemi Sebastiano
机构信息
Institute of Dermatology, University of Messina, Messina, Italy.
Department of Clinical and Experimental Medicine, School and Division of Allergy and Clinical Immunology, University of Messina, Messina, Italy.
出版信息
Int J Dermatol. 2015 Jun;54(6):672-4. doi: 10.1111/ijd.12392. Epub 2014 Nov 27.
INTRODUCTION
Vitiligo is a common progressive depigmentation of the skin due to selective destruction of melanocytes. Nowadays increasing evidences support the hypothesis of an autoimmune etiology.
METHODS
In order to sustain the role of T-helper-17 lymphocytes in the pathogenesis of vitiligo, we measured the serum levels of interleukin (IL)-23 (an important regulator of this subset) using a quantitative enzyme immunoassay technique in 12 males and 16 females (ages ranging from 18 to 58 years) affected by non-segmental vitiligo and compared the results with a group of healthy donors.
RESULTS
IL-23 serum levels were significantly higher in patients with vitiligo as compared with controls. There was a significant positive correlation of IL-23 serum levels with disease duration and extent of vitiligo and disease activity.
CONCLUSIONS
The inhibition of IL-23 might be a novel strategy in the therapy of autoimmune inflammatory diseases like vitiligo.
引言
白癜风是一种由于黑素细胞选择性破坏导致的常见进行性皮肤色素脱失病。如今，越来越多的证据支持自身免疫病因假说。
方法
为了证实辅助性T细胞17淋巴细胞在白癜风发病机制中的作用，我们采用定量酶免疫测定技术，对12名男性和16名女性（年龄在18至58岁之间）非节段性白癜风患者血清白细胞介素（IL）-23（该亚群的一种重要调节因子）水平进行了测定，并将结果与一组健康供者进行比较。
结果
与对照组相比，白癜风患者血清IL-23水平显著升高。血清IL-23水平与白癜风病程、病情严重程度及疾病活动度呈显著正相关。
结论
抑制IL-23可能是治疗白癜风等自身免疫性炎症疾病的一种新策略。
Zotero 插件