Kądziela Marcelina, Kutwin Magdalena, Karp Paulina, Woźniacka Anna
Department of Dermatology and Venereology, Medical University of Lodz, pl. Hallera 1, 90-647 Lodz, Poland.
J Clin Med. 2024 Aug 20;13(16):4919. doi: 10.3390/jcm13164919.
Vitiligo is a persistent autoimmune disease characterized by progressive depigmentation of the skin caused by the selective destruction of melanocytes. Although its etiopathogenesis remains unclear, multiple factors are involved in the development of this disease, from genetic and metabolic factors to cellular oxidative stress, melanocyte adhesion defects, and innate and adaptive immunity. This review presents a comprehensive summary of the existing knowledge on the role of different cellular mechanisms, including cytokines and chemokines interactions, in the pathogenesis of vitiligo. Although there is no definitive cure for vitiligo, notable progress has been made, and several treatments have shown favorable results. A thorough understanding of the basis of the disease uncovers promising drug targets for future research, providing clinical researchers with valuable insights for developing improved treatment options.
白癜风是一种持续性自身免疫性疾病，其特征是黑素细胞被选择性破坏导致皮肤进行性色素脱失。尽管其发病机制尚不清楚，但多种因素参与了该疾病的发生发展，从遗传和代谢因素到细胞氧化应激、黑素细胞黏附缺陷以及固有免疫和适应性免疫。本综述全面总结了关于不同细胞机制（包括细胞因子和趋化因子相互作用）在白癜风发病机制中作用的现有知识。虽然白癜风尚无根治方法，但已取得显著进展，几种治疗方法已显示出良好效果。对该疾病基础的深入理解揭示了未来研究中有望成为药物靶点的方向，为临床研究人员开发改进的治疗方案提供了有价值的见解。
