Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mediators Inflamm. 2021 Jul 12;2021:5578568. doi: 10.1155/2021/5578568. eCollection 2021.
Lichen planus is considered a chronic inflammatory disease which affects different sites, such as the skin, mucous membranes, hair, and nails. Based on the evidence, a complex cytokine network plays a crucial role in lichen planus pathogenesis. The study was aimed at assessing the serum IL-23 levels in the patients with cutaneous and oral lichen planus compared to healthy controls. . The study included 30 cutaneous lichen planus patients, 20 oral lichen planus patients, and 33 control subjects. Five milliliters of peripheral blood was obtained from each patient, and the serum was separated. IL-23 levels were determined using the ELISA kit, and the data were analyzed using the Mann-Whitney test. . IL-23 levels in the patient serum with oral lichen planus ( value ≤ 0.001) were significantly higher than in controls. Furthermore, there were significant differences in IL-23 serum levels in the patients with cutaneous lichen planus compared to the healthy controls ( value ≤ 0.001). Moreover, IL-23 serum levels were statistically different between patients with cutaneous lichen planus and patients with oral lichen planus ( value ≤ 0.001). Based on the mean concentration of interleukin-23, IL-23 levels were higher in the patients with oral lichen planus than in the patients with cutaneous lichen planus. . Elevated serum IL-23 levels in the patients with oral lichen planus may indicate that IL-23 plays a crucial role in the pathogenesis of oral lichen planus. However, more research is needed with a larger sample size.
扁平苔藓被认为是一种影响不同部位的慢性炎症性疾病，如皮肤、粘膜、毛发和指甲。基于证据，复杂的细胞因子网络在扁平苔藓发病机制中起着至关重要的作用。本研究旨在评估皮肤和口腔扁平苔藓患者与健康对照组相比血清 IL-23 水平。研究包括 30 例皮肤扁平苔藓患者、20 例口腔扁平苔藓患者和 33 例对照组。从每位患者中抽取 5 毫升外周血，分离血清。使用 ELISA 试剂盒测定 IL-23 水平，采用 Mann-Whitney 检验分析数据。口腔扁平苔藓患者血清中 IL-23 水平显著升高（P 值≤0.001）。此外，与健康对照组相比，皮肤扁平苔藓患者血清中 IL-23 水平差异有统计学意义（P 值≤0.001）。此外，皮肤扁平苔藓患者与口腔扁平苔藓患者之间血清 IL-23 水平差异有统计学意义（P 值≤0.001）。基于白细胞介素-23 的平均浓度，口腔扁平苔藓患者的血清 IL-23 水平高于皮肤扁平苔藓患者。口腔扁平苔藓患者血清中升高的 IL-23 水平可能表明 IL-23 在口腔扁平苔藓的发病机制中起着至关重要的作用。然而，需要更大的样本量进行更多的研究。
