Bolwell C F, Gilpin B J, Campbell D, French N P
Molecular Epidemiology and Public Health Laboratory,Infectious Disease Research Centre,Hopkirk Research Institute, Massey University,Palmerston North,New Zealand.
Institute of Environmental Science & Research Ltd,Christchurch,New Zealand.
Epidemiol Infect. 2015 Jul;143(9):1990-2002. doi: 10.1017/S0950268814003173. Epub 2014 Nov 27.
It is important to assess the suitability of sentinel sites for human disease; however, there have been few publications documenting the process of formal evaluation. We describe an approach to examining the representativeness of a single sentinel site employed for campylobacteriosis surveillance and source attribution, utilizing a selection of data sources and statistical comparisons of demographic, epidemiological and pathogen genotyping data across selected regions of New Zealand. Our findings showed that while this region captured the national variability in many variables, for example by containing sizable urban and rural populations, the relative frequency of these features did vary from other regions of New Zealand. We discuss the value of choosing a sentinel site that represents the national distribution of key variables, compared to a site that captures the broad features of the wider population, but provides greater power for the monitoring of sub-populations.
评估哨点对于人类疾病的适用性很重要;然而,很少有出版物记录正式评估的过程。我们描述了一种方法,通过选择一系列数据源,并对新西兰选定地区的人口统计学、流行病学和病原体基因分型数据进行统计比较,来检验用于弯曲杆菌病监测和来源归因的单个哨点的代表性。我们的研究结果表明,虽然该地区在许多变量上体现了全国的变异性,例如包含规模可观的城市和农村人口,但这些特征的相对频率与新西兰其他地区确实有所不同。我们讨论了选择一个代表关键变量全国分布的哨点的价值,相较于一个能体现更广泛人群广泛特征,但为亚人群监测提供更强效力的哨点。