Sun Yan, Wu Yan, Xiao Bihuan, Li Lu, Li Li, Chen Hong-Duo, Gao Xing-Hua
Department of Dermatology, No. 1 Hospital of China Medical University , Shenyang , China.
J Dermatolog Treat. 2015;26(4):347-53. doi: 10.3109/09546634.2014.991268. Epub 2015 Jan 30.
Vitiligo is an acquired cutaneous hypopigmentary disorder, which characterized by solitary or multiple depigmented maculae or patches. The 308-nm excimer laser has been used as phototherapy on vitiligo.
To evaluate the efficacy and safety of 308-nm excimer laser on vitiligo.
Randomized controlled trials were searched to conduct a systematic review. The keywords were identified as laser/excimer laser/quasimolecule/XeCl" and "vitiligo".
Seven studies with 390 vitiligo patients were included. No significant differences were seen between 308-nm excimer laser and 308-nm excimer lamp on either ≥75% or ≥50% re-pigmentation rate, or between 308-nm excimer laser and narrowband-ultraviolet B (NB-UVB) on either 100% or ≥75% re-pigmentation rate. More patients or lesions achieved ≥50% re-pigmentation rate by 308-nm excimer laser treatment than by NB-UVB treatment. The side effects of 308-nm excimer laser were slight and tolerable.
The 308-nm excimer laser showed equivalent efficacies to 308-nm excimer lamp control and NB-UVB control concerning ≥75% re-pigmentation rate of vitiligo patches. More studies with high methodological quality, low risk of bias and more sample size are needed to confirm the conclusion.
白癜风是一种获得性皮肤色素减退性疾病，其特征为单发或多发色素脱失斑。308纳米准分子激光已被用作白癜风的光疗方法。
评估308纳米准分子激光治疗白癜风的疗效和安全性。
检索随机对照试验以进行系统评价。确定的关键词为“激光/准分子激光/准分子/XeCl”和“白癜风”。
纳入了7项研究，共390例白癜风患者。在色素再沉着率≥75%或≥50%方面，308纳米准分子激光与308纳米准分子光疗灯之间无显著差异；在色素再沉着率100%或≥75%方面，308纳米准分子激光与窄谱中波紫外线（NB-UVB）之间也无显著差异。与NB-UVB治疗相比，更多患者或皮损经308纳米准分子激光治疗后色素再沉着率≥50%。308纳米准分子激光的副作用轻微且可耐受。
就白癜风斑块色素再沉着率≥75%而言，308纳米准分子激光与308纳米准分子光疗灯对照及NB-UVB对照显示出相当的疗效。需要更多方法学质量高、偏倚风险低且样本量更大的研究来证实这一结论。
