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[白癜风的治疗]

[Treatment of vitiligo].

作者信息

Meurer M, Schild M

机构信息

Stiftung zur Förderung der Hochschulmedizin in Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.

Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus, Dresden, Deutschland.

出版信息

Hautarzt. 2016 Mar;67(3):249-64. doi: 10.1007/s00105-016-3768-4.

DOI:10.1007/s00105-016-3768-4
PMID:26909811
Abstract

The range of treatment options for vitiligo has significantly expanded in the last 10 years and we can offer our patients more effective treatment strategies supported by European guidelines and consensus findings. Topical and UV therapy are-often in combination-the main components of vitiligo treatment. The main outcome parameters include extent and maintenance of gained repigmentation, cessation of spreading, avoidance of side effects and the influence of the treatment on the quality of life. The efficacy of the currently available treatments is often limited. New options include antioxidative or melanocyte-stimulating adjuvant therapies in combination with UV or laser light as well as a topical maintenance treatment to reduce the risk of recurrences. In many cases, psychological support is indicated.

摘要

在过去10年中,白癜风的治疗选择范围显著扩大,我们可以为患者提供更多由欧洲指南和共识结果支持的有效治疗策略。局部治疗和紫外线治疗通常联合使用,是白癜风治疗的主要组成部分。主要的疗效参数包括色素再生的范围和维持情况、白斑停止扩散、避免副作用以及治疗对生活质量的影响。目前可用治疗方法的疗效往往有限。新的选择包括抗氧化或刺激黑素细胞的辅助疗法与紫外线或激光联合使用,以及局部维持治疗以降低复发风险。在许多情况下,需要给予心理支持。

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1
[Treatment of vitiligo].[白癜风的治疗]
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2
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Vitiligo. Pathogenesis and treatment.白癜风。发病机制与治疗。
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Phototherapy for vitiligo, what's new?白癜风的光疗,有哪些新进展?
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引用本文的文献

1
[Systemic treatment of vitiligo : Balance and current developments].[白癜风的系统治疗:现状与新进展]
Hautarzt. 2017 Nov;68(11):876-884. doi: 10.1007/s00105-017-4065-6.
2
Epidermal skin grafting in vitiligo: a pilot study.白癜风的表皮皮肤移植:一项初步研究。
Int Wound J. 2016 Sep;13 Suppl 3(Suppl 3):47-51. doi: 10.1111/iwj.12632.

本文引用的文献

1
[Vitiligo: Clinical presentation and pathogenesis].[白癜风:临床表现与发病机制]
Hautarzt. 2016 Feb;67(2):173-86; quiz 187-9. doi: 10.1007/s00105-015-3751-5.
2
A Randomized Comparative Study of Oral Corticosteroid Minipulse and Low-Dose Oral Methotrexate in the Treatment of Unstable Vitiligo.口服皮质类固醇微脉冲与低剂量口服甲氨蝶呤治疗不稳定型白癜风的随机对照研究
Dermatology. 2015;231(3):286-90. doi: 10.1159/000433424. Epub 2015 Aug 8.
3
Bilobalide protection of normal human melanocytes from hydrogen peroxide-induced oxidative damage via promotion of antioxidase expression and inhibition of endoplasmic reticulum stress.
白果内酯通过促进抗氧化酶表达和抑制内质网应激保护正常人黑素细胞免受过氧化氢诱导的氧化损伤。
Clin Exp Dermatol. 2016 Jan;41(1):64-73. doi: 10.1111/ced.12664. Epub 2015 Jul 14.
4
Tumour necrosis factor-α inhibition can stabilize disease in progressive vitiligo.肿瘤坏死因子-α抑制可使进展期白癜风的病情稳定。
Br J Dermatol. 2015 Sep;173(3):641-50. doi: 10.1111/bjd.14016. Epub 2015 Aug 25.
5
Tofacitinib Citrate for the Treatment of Vitiligo: A Pathogenesis-Directed Therapy.枸橼酸托法替布治疗白癜风:一种针对发病机制的治疗方法。
JAMA Dermatol. 2015 Oct;151(10):1110-2. doi: 10.1001/jamadermatol.2015.1520.
6
Narrow Band Ultraviolet B Treatment for Human Vitiligo Is Associated with Proliferation, Migration, and Differentiation of Melanocyte Precursors.窄谱中波紫外线治疗人类白癜风与黑素细胞前体的增殖、迁移和分化相关。
J Invest Dermatol. 2015 Aug;135(8):2068-2076. doi: 10.1038/jid.2015.126. Epub 2015 Mar 30.
7
Quality of life and psychological morbidity in vitiligo patients: a study in a teaching hospital from north-East India.白癜风患者的生活质量与心理疾病:印度东北部一家教学医院的研究
Indian J Dermatol. 2015 Mar-Apr;60(2):142-6. doi: 10.4103/0019-5154.152508.
8
Interventions for vitiligo.白癜风的干预措施。
Cochrane Database Syst Rev. 2015 Feb 24;2015(2):CD003263. doi: 10.1002/14651858.CD003263.pub5.
9
Developing core outcome set for vitiligo clinical trials: international e-Delphi consensus.制定白癜风临床试验的核心结局集:国际电子德尔菲共识
Pigment Cell Melanoma Res. 2015 May;28(3):363-9. doi: 10.1111/pcmr.12354. Epub 2015 Feb 13.
10
Vitiligo.白癜风。
Lancet. 2015 Jul 4;386(9988):74-84. doi: 10.1016/S0140-6736(14)60763-7. Epub 2015 Jan 15.