Division of Rheumatology, Department of Physical Medicine and Rehabilitation, ERU Gevher Nesibe Hospital, Kayseri,
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, ERU Gevher Nesibe Hospital, Kayseri, Turkey.
Med Princ Pract. 2018;27(6):537-542. doi: 10.1159/000493480. Epub 2018 Sep 5.
The aim of the study was to compare characteristics of pain in terms of neuropathic pain (NeP) and to assess the association between the neuropathic component and quality of life (QoL) in patients with systemic sclerosis (SSc) and rheumatoid arthritis (RA).
Fifty-four patients (47 females, 7 males) with SSc and 53 patients (46 females, 7 males) with RA were assessed for outcome measures including disease activity, physical functions, mental condition and health-related QoL (HRQoL) measures (Short Form-36; Hospital Anxiety and Depression Scale), and pain. NeP was assessed by the Douleur Neuropathique 4 (DN4) and PainDetect questionnaires in this cross-sectional study.
The patients had similar education, smoking status, functioning, and HRQoL. However, the patients with RA declared a more severe visual analogue scale of pain and a higher BMI than those with SSc. The NeP component was detected in 42.6% (n = 23) of the SSc patients and in 45.3% (n = 24) of the RA patients (p > 0.05) according to DN4. On PainDetect, possible NeP was detected in 13.0% (n = 7) versus 15.1% (n = 8), whereas 16.7% (n = 9) versus 17.0% (n = 9) were likely to have NeP in SSc and RA, respectively (p > 0.05). Most of the NeP characteristics were similar in SSc and RA, except for numbness and painful cold, which were notably more common in patients with SSc. Having the NeP component (according to DN4) had no influence on functioning and HRQoL in SSc; however, the NeP component revealed a heavier burden of disease regarding functional status, HRQoL, and psychometric components in RA.
The NeP component was similar between patients with SSc and RA. However, NeP was associated with a heavier burden of disease in patients with RA.
本研究旨在比较系统性硬化症（SSc）和类风湿关节炎（RA）患者疼痛特征，评估神经病理性疼痛（NeP）与生活质量（QoL）之间的相关性。
本横断面研究共纳入 54 例 SSc 患者（47 名女性，7 名男性）和 53 例 RA 患者（46 名女性，7 名男性），评估其结局指标，包括疾病活动度、躯体功能、精神状态和健康相关 QoL（SF-36、医院焦虑抑郁量表），以及疼痛。本研究采用 Douleur Neuropathique 4（DN4）和 PainDetect 问卷评估 NeP。
两组患者的教育程度、吸烟状况、躯体功能和 QoL 相似。然而，与 SSc 患者相比，RA 患者的视觉模拟评分疼痛和 BMI 更高。根据 DN4，SSc 患者中 42.6%（n=23）和 RA 患者中 45.3%（n=24）存在 NeP 成分（p>0.05）。在 PainDetect 上，SSc 患者中可能存在 NeP 的有 13.0%（n=7），RA 患者中可能存在 NeP 的有 15.1%（n=8），而 SSc 和 RA 患者中可能存在 NeP 的分别为 16.7%（n=9）和 17.0%（n=9）（p>0.05）。SSc 和 RA 患者的大多数 NeP 特征相似，除了麻木和冷痛，这些特征在 SSc 患者中更为常见。根据 DN4，SSc 患者的 NeP 成分与功能状态和 QoL 无关，但在 RA 患者中，NeP 成分与功能状态、QoL 和心理计量学因素的疾病负担更重有关。
SSc 和 RA 患者的 NeP 成分相似。然而，NeP 与 RA 患者的疾病负担更重有关。
