Kakihara Yoshito, Saeki Makio
Biomol Concepts. 2014 Dec;5(6):513-20. doi: 10.1515/bmc-2014-0028.
R2TP was originally identified in yeast Saccharomyces cerevisiae as Hsp90 interacting complex, and is composed of four different proteins: Rvb1, Rvb2, Tah1, and Pih1. This complex is well-conserved in eukaryotes, and is involved in many cellular processes such as snoRNP biogenesis, RNA polymerase assembly, PIKK signaling, and apoptosis. An increasing number of research related to R2TP suggests a linkage of its function with tumorigenesis. In this review, we provide an overview of several recent studies on R2TP that are related to cell proliferation and carcinogenesis, and propose a possible role of R2TP in tumorigenesis through regulating snoRNA/snoRNP biogenesis.
R2TP最初在酿酒酵母中被鉴定为与热休克蛋白90（Hsp90）相互作用的复合物，由四种不同的蛋白质组成：Rvb1、Rvb2、Tah1和Pih1。这种复合物在真核生物中高度保守，参与许多细胞过程，如小核仁核糖核蛋白（snoRNP）生物合成、RNA聚合酶组装、磷脂酰肌醇3激酶相关激酶（PIKK）信号传导和细胞凋亡。越来越多与R2TP相关的研究表明其功能与肿瘤发生有关。在本综述中，我们概述了最近几项关于R2TP与细胞增殖和致癌作用相关的研究，并提出R2TP可能通过调节小核仁RNA（snoRNA）/小核仁核糖核蛋白生物合成在肿瘤发生中发挥作用。
