Verbeek Martijn W C, Erkeland Stefan J, van der Velden Vincent H J
Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Biomedicines. 2022 May 24;10(6):1229. doi: 10.3390/biomedicines10061229.
Small nucleolar RNAs (snoRNAs) are responsible for post-transcriptional modification of ribosomal RNAs, transfer RNAs and small nuclear RNAs, and thereby have important regulatory functions in mRNA splicing and protein translation. Several studies have shown that snoRNAs are dysregulated in human cancer and may play a role in cancer initiation and progression. In this review, we focus on the role of snoRNAs in normal and malignant B-cell development. SnoRNA activity appears to be essential for normal B-cell differentiation and dysregulated expression of sno-RNAs is determined in B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, B-cell non-Hodgkin's lymphoma, and plasma cell neoplasms. SnoRNA expression is associated with cytogenetic/molecular subgroups and clinical outcome in patients with B-cell malignancies. Translocations involving snoRNAs have been described as well. Here, we discuss the different aspects of snoRNAs in B-cell malignancies and report on their role in oncogenic transformation, which may be useful for the development of novel diagnostic biomarkers or therapeutic targets.
小核仁RNA（snoRNA）负责核糖体RNA、转运RNA和小核RNA的转录后修饰，因此在mRNA剪接和蛋白质翻译中具有重要的调节功能。多项研究表明，snoRNA在人类癌症中表达失调，可能在癌症的发生和发展中发挥作用。在本综述中，我们重点关注snoRNA在正常和恶性B细胞发育中的作用。snoRNA活性似乎对正常B细胞分化至关重要，并且在B细胞急性淋巴细胞白血病、慢性淋巴细胞白血病、B细胞非霍奇金淋巴瘤和浆细胞瘤中确定了snoRNA的表达失调。snoRNA表达与B细胞恶性肿瘤患者的细胞遗传学/分子亚组及临床结果相关。也有涉及snoRNA的易位报道。在此，我们讨论snoRNA在B细胞恶性肿瘤中的不同方面，并报告它们在致癌转化中的作用，这可能有助于开发新的诊断生物标志物或治疗靶点。
