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通过代谢和物理化学性质管理各种健康问题的纳米药物的最新进展

Recent Developments in Nanomedicines for Management of Various Health Issues Via Metabolism and Physico-Chemical Properties.

作者信息

Rasool Mahmood, Naseer Muhammad Imran, Malik Arif, Manan Abdul, Ullah Ikram, Abid Noman Bin, Kim Myeong Ok, Qazi Mahmood Husain, Kamal Mohammad Amjad, Bibi Fehmida

机构信息

Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, 21589 Saudi Arabia.

出版信息

Curr Drug Metab. 2015;16(5):389-96. doi: 10.2174/1389200215666141125121211.

Abstract

During the last decade the nanotechnologists began research on applications of nanomaterials for medicine and therapeutics. Various nanoparticles (nanomedicines) are being used worldwide for the diagnosis and management in a number of disorders including cancer and neurodegenerative disorders. The successful non-viral gene therapy is now possible with the advancements in nanotechnology. Mostly nanoparticles are divided into two main classes: organic and inorganic nanoparticles. Diverse features of nanomedicines with surface modification help to make them biocompatible with addition of varying polymer that facilitates targeted delivery of drug and its controlled release into the cells, tissues and organs. Liposomes, quantum dots, silver and gold nanoparticles are the most common examples of nanomedicines.

摘要

在过去十年中,纳米技术专家开始研究纳米材料在医学和治疗学中的应用。各种纳米颗粒(纳米药物)正在全球范围内用于多种疾病的诊断和管理,包括癌症和神经退行性疾病。随着纳米技术的进步,成功的非病毒基因治疗现在成为可能。大多数纳米颗粒主要分为两类:有机纳米颗粒和无机纳米颗粒。具有表面修饰的纳米药物的多种特性有助于使其具有生物相容性,同时添加不同的聚合物可促进药物的靶向递送及其在细胞、组织和器官中的控释。脂质体、量子点、银纳米颗粒和金纳米颗粒是纳米药物最常见的例子。

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