Department of Radiation Physics, Princess Margaret Hospital, University Health Network, STTARR Innovation Centre, Toronto, ON, Canada.
Recent Pat Nanotechnol. 2010 Nov;4(3):171-80. doi: 10.2174/187221010792483726.
Nanotechnology involves creation and utilization of materials, devices or systems on the nanometer scale. The field of nanotechnology is currently undergoing explosive development on many fronts. The technology is expected to generate innovations and play a critical role in drug delivery and imaging. There has been tremendous progress made in the use of polymer and lipid based nanoparticles (NPs) for drug delivery and imaging. Recently, more attention has been given to incorporating inorganic NPs such as gold and magnetic NPs with both imaging and therapeutic capabilities into polymer and lipid based NPs for improved therapy and imaging in cancer treatment. In this review article, the recent progress in the development of multiplex polymer, lipid, and inorganic NPs towards optimizing techniques for drug delivery and multimodal imaging will be discussed along with the relevant patents.
纳米技术涉及纳米尺度的材料、器件或系统的创造和利用。纳米技术领域目前在许多方面都在迅猛发展。该技术有望带来创新，并在药物输送和成像方面发挥关键作用。在使用聚合物和脂质纳米粒子（NPs）进行药物输送和成像方面已经取得了巨大进展。最近，人们越来越关注将具有成像和治疗能力的无机纳米粒子（如金和磁性纳米粒子）与聚合物和脂质纳米粒子结合，以提高癌症治疗的治疗效果和成像效果。在这篇综述文章中，将讨论朝着优化药物输送和多模态成像技术的方向发展的多模式聚合物、脂质和无机 NPs 的最新进展，并讨论相关专利。
