用于癌症传感、成像和治疗的纳米技术。

Nanotechnology for sensing, imaging, and treating cancer.

作者信息

Panchapakesan Balaji, Wickstrom Eric

机构信息

Delaware MEMS and Nanotechnology Laboratory, Department of Electrical and Computer Engineering, University of Delaware, Newark, DE 19716, USA.

出版信息

Surg Oncol Clin N Am. 2007 Apr;16(2):293-305. doi: 10.1016/j.soc.2007.03.002.

DOI:10.1016/j.soc.2007.03.002

PMID:17560513

Abstract

Nanotechnology encompasses the creation and use of materials, devices, and systems at the level of atoms, molecules, and supramolecular structures. Nanotechnology for cancer consists of three main areas: (1) nanodetectors for sensing proteins and cancer cells, (2) nanoparticle or nanovector formulations for high-contrast imaging, and (3) nanotechnology-based drug delivery and therapeutic formulations. Although there are tremendous challenges facing nanotechnologists, nanotechnology, if properly integrated with established cancer research, can make laboratory-to-clinic transfer of technology successful, which can result in breakthrough potential for patient care.

摘要

纳米技术涵盖了在原子、分子和超分子结构层面上材料、器件及系统的创造与应用。癌症纳米技术主要包括三个领域：（1）用于检测蛋白质和癌细胞的纳米探测器；（2）用于高对比度成像的纳米颗粒或纳米载体制剂；（3）基于纳米技术的药物递送和治疗制剂。尽管纳米技术专家面临着巨大挑战，但如果能将纳米技术与已有的癌症研究恰当整合，就能使技术从实验室成功转化到临床应用，从而为患者护理带来突破性的潜力。