肌醇磷脂连接型谷氨酸受体介导小脑平行纤维-浦肯野细胞突触传递。
Inositolphospholipid-linked glutamate receptors mediate cerebellar parallel-fiber-Purkinje-cell synaptic transmission.
作者信息
Blackstone C D, Supattapone S, Snyder S H
机构信息
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
出版信息
Proc Natl Acad Sci U S A. 1989 Jun;86(11):4316-20. doi: 10.1073/pnas.86.11.4316.
Abstract
In slices of adult rat cerebellum inositolphospholipid turnover is stimulated markedly by glutamate and its rigid analogues quisqualate and ibotenate. The drug and amino acid specificity of the response reflects a quisqualate-preferring excitatory amino acid receptor. The absence of glutamate-enhanced inositolphospholipid turnover in mice with Purkinje-cell degeneration indicates that the inositolphospholipid-linked quisqualate receptor mediates parallel fiber-Purkinje cell synaptic transmission. The quantitative prominence of this synapse accounts for the massive enrichment of elements of the inositolphospholipid system in cerebellar Purkinje cells.
摘要
在成年大鼠小脑切片中，谷氨酸及其刚性类似物quisqualate和鹅膏蕈氨酸能显著刺激肌醇磷脂转换。该反应的药物和氨基酸特异性反映了一种对quisqualate更具亲和力的兴奋性氨基酸受体。在患有浦肯野细胞变性的小鼠中，谷氨酸增强的肌醇磷脂转换缺失，这表明与肌醇磷脂相连的quisqualate受体介导了平行纤维 - 浦肯野细胞的突触传递。这种突触在数量上的突出地位解释了小脑浦肯野细胞中肌醇磷脂系统成分的大量富集。
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