Veronesi U
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Semin Surg Oncol. 1989;5(2):145-50. doi: 10.1002/ssu.2980050211.
Minimal breast cancer includes three different entities: lobular carcinoma in situ, noninfiltrating intraductal carcinoma, and invasive carcinoma less than 0.5 cm. The common feature is their small dimensions and the fact that they are often clinically occult. For lobular carcinoma in situ the risk of developing an invasive carcinoma varies from seven to nine times compared with the general population and a careful follow-up of the patients with frequent mammograms is therefore suggested. Intraductal noninfiltrating carcinoma should be locally treated as an invasive carcinoma of small size, and therefore an extensive mammary resection like the quadrantectomy, plus radiotherapy is the recommended form of treatment, while the axillary dissection may be avoided. Finally, small invasive carcinomas should be treated with conservative procedures, including a total axillary dissection.
小叶原位癌、非浸润性导管内癌和直径小于0.5厘米的浸润性癌。其共同特点是体积小，且临床上常难以发现。小叶原位癌发展为浸润性癌的风险相较于普通人群高出7至9倍，因此建议对患者进行密切随访，定期进行乳房X光检查。非浸润性导管内癌应按小尺寸浸润性癌进行局部治疗，因此推荐采用如象限切除术加放疗等广泛的乳房切除术，而腋窝淋巴结清扫术可避免。最后，小的浸润性癌应采用保守治疗方法，包括全腋窝淋巴结清扫术。
