Hartmann W H
Cancer. 1984 Feb 1;53(3 Suppl):681-4. doi: 10.1002/1097-0142(19840201)53:3+<681::aid-cncr2820531315>3.0.co;2-3.
In 1971, minimal carcinoma of the breast was defined as those carcinomas which were duct carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and those invasive carcinomas that measured 5 mm or less in greatest diameter. Since then the concept has been challenged; the definition has been modified; there has been new knowledge about the forms of carcinoma included in the definition with reference to natural history and response to therapy and there has been documented experience with patients who have minimal mammary carcinoma. These all re-enforce the validity of the original concept. The author reviews this information as well as that of some of the patients of the Breast Cancer Detection and Demonstration Projects jointly sponsored by the American Cancer Society and the National Cancer Institute, discusses some problems with specimen handling, and identifies areas that need additional study.
1971年，微小乳腺癌被定义为导管原位癌（DCIS）、小叶原位癌（LCIS）以及最大直径小于或等于5毫米的浸润性癌。自那时起，这一概念受到了挑战；定义得到了修改；对于定义中所包含的癌的形式，在自然史和对治疗的反应方面有了新的认识，并且有了关于微小乳腺癌患者的文献记载经验。所有这些都强化了原始概念的有效性。作者回顾了这些信息以及由美国癌症协会和美国国立癌症研究所联合发起的乳腺癌检测与示范项目中部分患者的信息，讨论了标本处理方面的一些问题，并确定了需要进一步研究的领域。
