Chun Colleen S, Weinmann Sheila, Riedlinger Karen, Mullooly John P
Pediatric Infectious Diseases Specialist for Northwest Permanente in Portland, OR.
Investigator at the Center for Health Research in Portland, OR.
Perm J. 2015 Winter;19(1):38-43. doi: 10.7812/TPP/14-010. Epub 2014 Nov 24.
To investigate whether passive cigarette smoke exposure increases the risk of invasive pneumococcal disease in children.
In a population-based case-control study, 171 children aged 0 to 12 years with culture-confirmed invasive pneumococcal disease during the years 1994 to 2004 were identified. Two controls were matched to each case on age and patterns of Health Plan membership. We reviewed medical records of subjects and family members for information on household cigarette smoke exposure within 2 years of the diagnosis of invasive pneumococcal disease. We collected information on sex, race, pneumococcal vaccination, selected medical conditions, and medications in the 3 months before the diagnosis.
Similar proportions of cases (25%) and controls (30%) had definite or probable passive smoke exposure (odds ratio [OR] = 0.76, 95% confidence interval [CI] = 0.47-1.2). Cases of invasive pneumococcal disease were more likely to be nonwhite than controls (OR = 4.4, 95% CI = 2.3-8.2). Elevated risk of invasive pneumococcal disease was found in subjects with recent pulmonary diagnoses (OR = 2.2, 95% CI = 1.2-4.0) and recent antibiotic use (OR = 1.6, 95% CI = 1.1-2.3).
Passive cigarette smoke exposure was not associated with invasive pneumococcal disease in this pediatric population. Invasive pneumococcal disease was associated with recent pulmonary diagnoses and recent antibiotic use.
研究被动接触香烟烟雾是否会增加儿童侵袭性肺炎球菌病的风险。
在一项基于人群的病例对照研究中，确定了1994年至2004年间171名年龄在0至12岁、经培养确诊为侵袭性肺炎球菌病的儿童。为每个病例匹配两名年龄和健康计划参保模式相同的对照。我们查阅了受试者及其家庭成员的医疗记录，以获取侵袭性肺炎球菌病诊断前2年内家庭香烟烟雾暴露的信息。我们收集了诊断前3个月内的性别、种族、肺炎球菌疫苗接种情况、选定的医疗状况和用药信息。
病例组（25%）和对照组（30%）中被动吸烟明确或可能的比例相似（优势比[OR]=0.76，95%置信区间[CI]=0.47-1.2）。侵袭性肺炎球菌病病例比对照组更可能是非白人（OR=4.4，95%CI=2.3-8.2）。近期有肺部诊断的受试者（OR=2.2，95%CI=1.2-4.0）和近期使用抗生素的受试者（OR=1.6，95%CI=1.1-2.3）侵袭性肺炎球菌病风险升高。
在该儿科人群中，被动接触香烟烟雾与侵袭性肺炎球菌病无关。侵袭性肺炎球菌病与近期肺部诊断和近期使用抗生素有关。
