Jiang Jia-Hao, Liu Chen, Cheng He, Lu Yu, Qin Yi, Xu Yong-Feng, Xu Jin, Long Jiang, Liu Liang, Ni Quan-Xing, Yu Xian-Jun
Department of Pancreatic and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, PR China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, PR China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, PR China.
Department of Pancreatic and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, PR China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, PR China.
Biochim Biophys Acta. 2015 Jan;1855(1):43-9. doi: 10.1016/j.bbcan.2014.11.004. Epub 2014 Nov 26.
Pancreatic cancer is one of the most aggressive solid malignancies. This aggressiveness is partly attributable to extensive local tumor invasion and early systemic dissemination as well as resistance to chemotherapy. Epithelial-mesenchymal transition (EMT) plays fundamental roles in embryonic development and in the differentiation of normal tissues and organs. EMT also plays critical roles in tumor formation, dissemination and drug resistance in pancreatic cancer. Emerging data suggest that inhibiting EMT may reverse the EMT phenotype and enhance the efficacy of chemotherapeutic agents against pancreatic cancer cells. Thus, an understanding of the molecular biology of EMT in pancreatic cancer may provide insights into the mechanisms of tumor invasion and metastatic progression and facilitate the development of alternative therapeutic approaches to improve the treatment outcomes for patients suffering from pancreatic cancer.
胰腺癌是最具侵袭性的实体恶性肿瘤之一。这种侵袭性部分归因于广泛的局部肿瘤浸润、早期全身播散以及对化疗的耐药性。上皮-间质转化（EMT）在胚胎发育以及正常组织和器官的分化中发挥着重要作用。EMT在胰腺癌的肿瘤形成、播散和耐药性方面也起着关键作用。新出现的数据表明，抑制EMT可能会逆转EMT表型，并增强化疗药物对胰腺癌细胞的疗效。因此，了解胰腺癌中EMT的分子生物学可能有助于深入了解肿瘤侵袭和转移进展的机制，并促进开发替代治疗方法，以改善胰腺癌患者的治疗效果。
