溶血磷脂酸信号通路在肠上皮中的多种作用。
Diverse roles of LPA signaling in the intestinal epithelium.
作者信息
Yun C Chris, Kumar Ajay
机构信息
Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA; Atlanta VA Medical Center, Decatur, GA, USA.
Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
出版信息
Exp Cell Res. 2015 May 1;333(2):201-207. doi: 10.1016/j.yexcr.2014.11.013. Epub 2014 Nov 26.
Abstract
Lysophosphatidic acid (LPA) is a lipid mediator that modulates a wide variety of cellular functions. Elevated LPA signaling has been reported in patients with colorectal cancer or inflammatory bowel diseases, and the tumorigenic role of LPA has been demonstrated in experimental models of colon cancer. However, emerging evidence indicates the importance of LPA signaling in epithelial wound healing and regulation of intestinal electrolyte transport. Here, we briefly review current knowledge of the biological roles of LPA signaling in the intestinal tract.
摘要
溶血磷脂酸（LPA）是一种脂质介质，可调节多种细胞功能。据报道，在结直肠癌或炎症性肠病患者中，LPA信号传导增强，并且在结肠癌的实验模型中已证实LPA的致瘤作用。然而，新出现的证据表明LPA信号传导在上皮伤口愈合和肠道电解质转运调节中的重要性。在这里，我们简要回顾一下目前关于LPA信号传导在肠道中的生物学作用的知识。
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本文引用的文献
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J Lipid Res. 2014 Jul;55(7):1192-214. doi: 10.1194/jlr.R046458. Epub 2014 Mar 18.
2
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J Lipid Res. 2013 Dec;54(12):3403-18. doi: 10.1194/jlr.M042051. Epub 2013 Oct 1.
3
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4
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Lab Invest. 2013 May;93(5):508-19. doi: 10.1038/labinvest.2013.45. Epub 2013 Mar 11.
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