Huang Ying, Mylius Judith, Scheich Henning, Brosch Michael
Special Laboratory Primate Neurobiology, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany.
Emeritus Group Lifelong Learning, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany.
Brain Struct Funct. 2016 Mar;221(2):969-77. doi: 10.1007/s00429-014-0950-2. Epub 2014 Nov 30.
This study shows that ongoing electrical stimulation of the dopaminergic ventral midbrain can modify neuronal activity in the auditory cortex of awake primates for several seconds. This was reflected in a decrease of the spontaneous firing and in a bidirectional modification of the power of auditory evoked potentials. We consider that both effects are due to an increase in the dopamine tone in auditory cortex induced by the electrical stimulation. Thus, the dopaminergic ventral midbrain may contribute to the tonic activity in auditory cortex that has been proposed to be involved in associating events of auditory tasks (Brosch et al. Hear Res 271:66-73, 2011) and may modulate the signal-to-noise ratio of the responses to auditory stimuli.
本研究表明，对多巴胺能腹侧中脑进行持续电刺激可在数秒内改变清醒灵长类动物听觉皮层的神经元活动。这表现为自发放电减少以及听觉诱发电位功率的双向改变。我们认为这两种效应均归因于电刺激引起的听觉皮层多巴胺水平升高。因此，多巴胺能腹侧中脑可能有助于听觉皮层的紧张性活动，这种活动被认为与听觉任务中的事件关联有关（Brosch等人，《听觉研究》271:66 - 73，2011），并且可能调节对听觉刺激反应的信噪比。
