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细胞外基质调节听觉皮层的皮质层动态和柱间频率整合。

The extracellular matrix regulates cortical layer dynamics and cross-columnar frequency integration in the auditory cortex.

机构信息

Department of Systems Physiology of Learning, Leibniz Institute for Neurobiology, 39118, Magdeburg, Germany.

Optical neuroimaging unit, Okinawa Institute of Science and Technology, Okinawa, Japan.

出版信息

Commun Biol. 2021 Mar 10;4(1):322. doi: 10.1038/s42003-021-01837-4.

DOI:10.1038/s42003-021-01837-4
PMID:33692502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7946889/
Abstract

In the adult vertebrate brain, enzymatic removal of the extracellular matrix (ECM) is increasingly recognized to promote learning, memory recall, and restorative plasticity. The impact of the ECM on translaminar dynamics during cortical circuit processing is still not understood. Here, we removed the ECM in the primary auditory cortex (ACx) of adult Mongolian gerbils using local injections of hyaluronidase (HYase). Using laminar current-source density (CSD) analysis, we found layer-specific changes of the spatiotemporal synaptic patterns with increased cross-columnar integration and simultaneous weakening of early local sensory input processing within infragranular layers Vb. These changes had an oscillatory fingerprint within beta-band (25-36 Hz) selectively within infragranular layers Vb. To understand the laminar interaction dynamics after ECM digestion, we used time-domain conditional Granger causality (GC) measures to identify the increased drive of supragranular layers towards deeper infragranular layers. These results showed that ECM degradation altered translaminar cortical network dynamics with a stronger supragranular lead of the columnar response profile.

摘要

在成年脊椎动物大脑中，越来越多的研究表明，酶促去除细胞外基质 (ECM) 可以促进学习、记忆回忆和恢复性可塑性。然而，ECM 对皮质回路处理过程中的跨层动力学的影响仍不清楚。在这里，我们使用透明质酸酶 (HYase) 局部注射的方法去除了成年蒙古沙鼠初级听觉皮层 (ACx) 的 ECM。通过层电流源密度 (CSD) 分析，我们发现时空突触模式具有层特异性变化，跨柱状整合增加，同时颗粒下层 Vb 中早期局部感觉输入处理减弱。这些变化在颗粒下层 Vb 内选择性地具有β波段（25-36 Hz）的振荡特征。为了了解 ECM 消化后的层间相互作用动力学，我们使用时域条件格兰杰因果关系 (GC) 度量来识别颗粒上层向更深颗粒下层的驱动增加。这些结果表明，ECM 降解改变了跨层皮质网络动力学，柱状反应轮廓的颗粒上层具有更强的主导作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/dd599bda2d9b/42003_2021_1837_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/17f68402b10c/42003_2021_1837_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/a0b92cb0da01/42003_2021_1837_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/2aba201c6ec6/42003_2021_1837_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/76ace87a6132/42003_2021_1837_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/4c6d0370b28e/42003_2021_1837_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/dd599bda2d9b/42003_2021_1837_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/17f68402b10c/42003_2021_1837_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/a0b92cb0da01/42003_2021_1837_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/2aba201c6ec6/42003_2021_1837_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/76ace87a6132/42003_2021_1837_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/4c6d0370b28e/42003_2021_1837_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d44/7946889/dd599bda2d9b/42003_2021_1837_Fig6_HTML.jpg

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