Sara S J, Devauges V
Département de psychophysiologie, CNRS, Gif/Yvette, France.
Behav Neural Biol. 1989 May;51(3):401-11. doi: 10.1016/s0163-1047(89)91039-x.
The role of the noradrenergic system in cognitive function was studied by using the alpha-2 adrenoceptor antagonist idazoxan to increase noradrenergic activity. Rats were trained in a complex maze task for food reward. They were left undisturbed for a 4-week "forgetting" period and were treated with idazoxan, just before the retention test. The dose of idazoxan used had previously been shown to enhance firing of units of the locus coeruleus and to increase noradrenaline (NE) turnover in the forebrain. This pharmacological treatment effectively alleviated forgetting, while control rats showed significant decrement compared to their performance at the last training trial. A control experiment showed that the facilitative effect was not on learning or on ongoing performance of the task, since there was no effect on simple acquisition. The results are taken as support for the notion that NE plays a role in memory retrieval processes.
通过使用α-2肾上腺素能受体拮抗剂咪唑克生增加去甲肾上腺素能活性，研究了去甲肾上腺素能系统在认知功能中的作用。大鼠接受复杂迷宫任务训练以获取食物奖励。它们在为期4周的“遗忘”期内未受干扰，并在记忆测试前接受咪唑克生治疗。先前已证明所用剂量的咪唑克生可增强蓝斑核单位的放电并增加前脑去甲肾上腺素（NE）的周转率。这种药物治疗有效减轻了遗忘，而对照大鼠与上次训练试验时的表现相比有显著下降。一项对照实验表明，促进作用并非作用于学习或任务的持续表现，因为对简单习得没有影响。这些结果支持了NE在记忆检索过程中起作用这一观点。
